Lamotrigine (Epilepsy)

Oro-facial clefts

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8119
R24943		 Holmes, 2008 All isolated (Cleft palate alone, Cleft lip alone and Cleft lip and palate) 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No 10.40 [4.30;24.90] 5/684   145/206,224 150 684
ref
Total 1 studies 10.40 [4.32;25.03] 150 684
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Holmes, 2008Holmes, 2008 10.40[4.30; 24.90]1506840%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: moderate0.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 10.40[4.32; 25.03]150684 -NAHolmes, 2008 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 10.40[4.32; 25.03]150684 -NAHolmes, 2008 1 Tags Adjustment   - No  - No 10.40[4.32; 25.03]150684 -NAHolmes, 2008 1 All studiesAll studies 10.40[4.32; 25.03]150684 -NAHolmes, 2008 10.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale10.40[4.32; 25.03]150684 -NAHolmes, 2008 10.510.01.0