Lamotrigine (Epilepsy)

Cognitive developmental disorders/delay (3-6 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7277
R48894		 Kasradze, 2017 Full scale IQ - Wechsler Preschool and Primary Scale of Intelligence (WPPSI-4) (mean age 4-4.5 years old) during pregnancy (anytime or not specified) prospective cohort unexposed, disease free Adjustment: No extrapolated (cont. endpoint) Matched 30.10 [3.28;276.62] -/3   -/50 - 3
ref
S6295
R48895		 Rihtman, 2013 Stanford Binet Intelligence Scales, Fifth Edition (SB5) - GIQ (mean age 4-5 years old) at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No extrapolated (cont. endpoint) 1.65 [0.78;3.49] -/41   -/52 - 41
ref
S6940
R48893		 Cummings, 2011 Mild or significant delay (score ≥1, <2 SD or ≥2 SD below the mean) (Bayley Scales of Infant Development or the Griffiths Scale) (mean age in years: m1=2.7 and m0=4.3) throughout pregnancy retrospective cohort (registry) unexposed, disease free Adjustment: Yes 1.10 [0.10;13.70] 1/35   2/44 3 35
ref
Total 3 studies 3.39 [0.56;20.57] 3 79
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kasradze, 2017Kasradze, 2017 30.10[3.28; 276.62]-328%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: criticalROB mesure: lowROB reporting: moderate Rihtman, 2013Rihtman, 2013 1.65[0.78; 3.49]-4146%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Cummings, 2011Cummings, 2011 1.10[0.10; 13.70]33526%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: lowROB reporting: moderate Total (3 studies) I2 = 68% 3.39[0.56; 20.57]3790.5100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.39[0.56; 20.57]37968%NAKasradze, 2017 Rihtman, 2013 Cummings, 2011 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.39[0.56; 20.57]37968%NAKasradze, 2017 Rihtman, 2013 Cummings, 2011 3 Tags Adjustment   - No  - No 5.80[0.35; 97.25]-4483%NAKasradze, 2017 Rihtman, 2013 2   - Yes  - Yes 1.10[0.09; 12.88]335 -NACummings, 2011 1 extrapolated (cont. endpoint)extrapolated (cont. endpoint) 5.80[0.35; 97.25]-4483%NAKasradze, 2017 Rihtman, 2013 2 MatchedMatched 30.10[3.28; 276.42]-3 -NAKasradze, 2017 1 All studiesAll studies 3.39[0.56; 20.57]37968%NAKasradze, 2017 Rihtman, 2013 Cummings, 2011 30.5100.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.39[0.56; 20.57]37968%NAKasradze, 2017 Rihtman, 2013 Cummings, 2011 30.510.01.0