| id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S19447 R82910 |
Karayagmurlu (Controls unexposed, disease free) (Lamotrigine) (Epilepsy), 2026 | Autism Spectrum Disorder - DSM-5 clinical evaluation conducted by an experienced child and adolescent psychiatrist - Aged 2–6 years | during pregnancy (anytime or not specified) | retrospective cohort | unexposed, disease free excluded | Adjustment: No |
9.55 [0.17;530.22] C excluded (control group) |
0/6 0/53 | 0 | 6 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S19451 R82918 |
Karayagmurlu (Controls unexposed, sick) (Lamotrigine) (Epilepsy), 2026 | Autism Spectrum Disorder - DSM-5 clinical evaluation conducted by an experienced child and adolescent psychiatrist - Aged 2–6 years | during pregnancy (anytime or not specified) | retrospective cohort | unexposed, sick | Adjustment: No | 3.36 [0.06;189.98] C | 0/6 0/19 | 0 | 6 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S19477 R83183 |
Straub (Lamotrigine) (Epilepsy), 2026 | Autism spectrum disorder - ICD-10 codes: F84.x (except F84.2, F84.3) - Mean follow up (full cohort): 3.4 years | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | unexposed, sick | Adjustment: Yes | 0.96 [0.63;1.47] | 34/3,273 106/8,887 | 140 | 3,273 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S17430 R73223 |
Madley-Dowd_SE (Lamotrigine) (Controls unexposed, sick), 2024 | Autism - ICD-8/9/10 codes - Mean 5-20 years old (according groups) | during pregnancy (anytime or not specified) | population based cohort retrospective | unexposed, sick | Adjustment: Yes Partial overlapping | 0.81 [0.60;1.09] | 53/2,383 425/10,769 | 478 | 2,383 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S17251 R72249 |
Madley-Dowd_UK (Lamotrigine) (Epilepsy), 2024 | Autism - ICD10 codes - Median 6.18 (3.53-9.94) years old | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | unexposed, sick | Adjustment: Yes | 1.07 [0.62;1.85] | 17/791 78/4,075 | 95 | 791 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S15870 R65394 |
Dreier, 2023 | Autism spectrum disorder - Corresponding ICD-10 F-chapter - Up to 22 years of age | during pregnancy (anytime or not specified) | population based cohort propective | unexposed, sick | Adjustment: Yes | 0.86 [0.65;1.14] | 64/5,288 323/22,203 | 387 | 5,288 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S9930 R39724 |
Bjørk (Controls unexposed, disease free), 2018 | Autistic traits at 18 months and/or at 36 months (M-CHAT <2/6 critical or <3/23 or SCQ >13) | during pregnancy (anytime or not specified) | population based cohort propective | unexposed, disease free excluded | Adjustment: No |
2.05 [1.13;3.72] C excluded (control group) |
13/76 6,907/75,497 | 6,920 | 76 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S9974 R39725 |
Bjørk (Controls unexposed, sick), 2018 | Autistic traits at 18 months and/or at 36 months (M-CHAT <2/6 critical or <3/23 or SCQ >13) | during pregnancy (anytime or not specified) | population based cohort propective | unexposed, sick | Adjustment: No | 1.87 [0.91;3.84] C | 13/76 27/272 | 40 | 76 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S7964 R39753 |
Cohen-Israel, 2018 | Autism - Medical files and by a telephone interview using an ad-hoc questionnaire - A majority between 6-12 years old | 1st trimester | retrospective cohort | unexposed, disease free | Adjustment: No Matched | 0.33 [0.01;8.20] C | 0/83 1/83 | 1 | 83 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S6604 R39735 |
Bromley (Controls unexposed, disease free), 2013 | Autistic Spectrum Disorders (at 6 years old) | during pregnancy (anytime or not specified) | prospective cohort | unexposed, disease free excluded | Adjustment: No |
1.81 [0.20;16.76] C excluded (control group) |
1/30 4/214 | 5 | 30 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S6603 R39737 |
Bromley (Controls unexposed, sick), 2013 | Autistic Spectrum Disorders (at 6 years old) | during pregnancy (anytime or not specified) | prospective cohort | unexposed, sick | Adjustment: No | 2.68 [0.10;68.88] C | 1/30 0/26 | 1 | 30 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Total | 8 studies | 0.92 [0.78;1.09] | 1,142 | 11,930 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1: Controls unexposed, sick) (Lamotrigine) (Epilepsy; 2: Lamotrigine) (Epilepsy; 3: Lamotrigine) (Controls unexposed, sick; 4: Lamotrigine) (Epilepsy; 5: Controls unexposed, sick; 6: Controls unexposed, sick;
Asymetry test p-value = 0.2180 (by Egger's regression)
slope=-0.2254 (0.1272); intercept=0.7178 (0.5216); t=1.3761; p=0.2180
excluded 6604, 9930, 19447