Lamotrigine (Epilepsy)

Behavioral disorders

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15870
R65390		 Dreier, 2023 Oppositional defiant disorder and conduct disorder - Corresponding ICD-10 F-chapter - Up to 22 years of age during pregnancy (anytime or not specified) population based cohort propective unexposed, sick Adjustment: Yes 0.69 [0.39;1.22] 14/5,288   110/22,203 124 5,288
ref
S6394
R17467		 Veiby (Controls unexposed, disease free) b, 2013 Aggressive symptoms ≥ 2SD (at 36 months) (the Child Behaviour Checklist) during pregnancy (anytime or not specified) prospective cohort unexposed, disease free excluded Adjustment: No 1.60 [0.50;5.20]
excluded (control group) 		3/44   1,786/43,571 1,789 44
ref
S6393
R17448		 Veiby (Controls unexposed, sick) b, 2013 Aggressive symptoms ≥ 2SD (at 36 months) (the Child Behaviour Checklist) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 2.18 [0.50;9.51] C 3/44   5/154 8 44
ref
Total 2 studies 1.00 [0.35;2.85] 132 5,332
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Dreier, 2023Dreier, 2023 0.69[0.39; 1.22]1245,28868%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Veiby (Controls unexposed, sick) b, 2013Veiby, 2013 1 2.18[0.50; 9.51]84432%ROB confusion: seriousROB selection: lowROB classification: lowROB missing: moderateROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 51% 1.00[0.35; 2.85]1325,3320.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick) ;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.00[0.35; 2.85]1325,33251%NADreier, 2023 Veiby (Controls unexposed, sick) b, 2013 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.00[0.35; 2.85]1325,33251%NADreier, 2023 Veiby (Controls unexposed, sick) b, 2013 2 Tags Adjustment   - No  - No 2.18[0.50; 9.51]844 -NAVeiby (Controls unexposed, sick) b, 2013 1   - Yes  - Yes 0.69[0.39; 1.22]1245,288 -NADreier, 2023 1 All studiesAll studies 1.00[0.35; 2.85]1325,33251%NADreier, 2023 Veiby (Controls unexposed, sick) b, 2013 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 6394

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.60[0.50; 5.16]1,78944 -NAVeiby (Controls unexposed, disease free) b, 2013 1 unexposed, sick controlsunexposed, sick controls 1.00[0.35; 2.85]1325,33251%NADreier, 2023 Veiby (Controls unexposed, sick) b, 2013 20.510.01.0