Lamotrigine (Epilepsy)

ADHD (Attention deficit hyperactivity disorder): Risk

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6295
R24833		 Rihtman, 2013 Conners’ Parent - ADHD Index (Preschool children: mean age 4-5y) at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No extrapolated (cont. endpoint) 1.21 [0.57;2.56] -/39   -/52 - 39
ref
S6394
R17466		 Veiby (Controls unexposed, disease free) b, 2013 ADHD symptoms ≥ 2SD (at 36 months) (Specific checklist) (Parent-reported) during pregnancy (anytime or not specified) prospective cohort unexposed, disease free excluded Adjustment: No 1.50 [0.40;4.80]
excluded (control group) 		3/44   1,743/43,571 1,746 44
ref
S6393
R17447		 Veiby (Controls unexposed, sick) b, 2013 ADHD symptoms ≥ 2SD (at 36 months) (Specific checklist) (Parent-reported) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 2.74 [0.59;12.75] C 3/44   4/154 7 44
ref
Total 2 studies 1.42 [0.72;2.78] 7 83
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Rihtman, 2013Rihtman, 2013 1.21[0.57; 2.56]-3981%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Veiby (Controls unexposed, sick) b, 2013Veiby, 2013 1 2.74[0.59; 12.75]74419%ROB confusion: seriousROB selection: lowROB classification: lowROB missing: moderateROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.42[0.72; 2.78]7830.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick) ;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.42[0.72; 2.78]7830%NARihtman, 2013 Veiby (Controls unexposed, sick) b, 2013 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.21[0.57; 2.56]-39 -NARihtman, 2013 1 unexposed, sickunexposed, sick 2.74[0.59; 12.75]744 -NAVeiby (Controls unexposed, sick) b, 2013 1 Tags Adjustment   - No  - No 1.42[0.72; 2.78]7830%NARihtman, 2013 Veiby (Controls unexposed, sick) b, 2013 2 extrapolated (cont. endpoint)extrapolated (cont. endpoint) 1.21[0.57; 2.56]-39 -NARihtman, 2013 1 All studiesAll studies 1.42[0.72; 2.78]7830%NARihtman, 2013 Veiby (Controls unexposed, sick) b, 2013 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 6394

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.28[0.67; 2.44]1,746830%NARihtman, 2013 Veiby (Controls unexposed, disease free) b, 2013 2 unexposed, sick controlsunexposed, sick controls 2.74[0.59; 12.75]744 -NAVeiby (Controls unexposed, sick) b, 2013 10.510.01.0