Lamotrigine (Epilepsy)

Low Apgar score (< 7) (at 5 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5912
R14918		 Artama (Controls unexposed, disease free), 2013 5-min Apgar <7 3rd trimester population based cohort retrospective unexposed, disease free excluded Adjustment: Yes 1.69 [0.53;5.36]
excluded (control group) 		3/132   3,014/269,151 3,017 132
ref
S5920
R15014		 Artama (Controls unexposed, sick), 2013 5-min Apgar <7 3rd trimester population based cohort retrospective unexposed, sick Adjustment: Yes 1.89 [0.46;7.76] 3/132   3/652 6 132
ref
S6394
R17468		 Veiby (Controls unexposed, disease free) b, 2013 Low Apgar score (< 7 at 5 min) during pregnancy (anytime or not specified) prospective cohort unexposed, disease free excluded Adjustment: No 1.20 [0.30;4.80]
excluded (control group) 		2/103   1,710/106,899 1,712 103
ref
S6393
R17449		 Veiby (Controls unexposed, sick) b, 2013 Low Apgar score (< 7 at 5 min) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 0.83 [0.18;3.90] C 2/103   9/386 11 103
ref
S6260
R16726		 Borthen (Controls unexposed, disease free), 2010 Apgar < 7 after 5 minutes during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free excluded Adjustment: Yes 1.90 [0.90;4.00]
excluded (control group) 		7/233   6,022/362,302 6,029 233
ref
S6265
R16766		 Borthen (Controls unexposed, sick), 2010 Apgar < 7 after 5 minutes during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: No 1.89 [0.82;4.36] C 7/233   30/1,863 37 233
ref
Total 3 studies 1.63 [0.85;3.14] 54 468
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Artama (Controls unexposed, sick), 2013Artama, 2013 1 1.89[0.46; 7.76]613221%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Veiby (Controls unexposed, sick) b, 2013Veiby, 2013 2 0.83[0.18; 3.90]1110318%ROB confusion: unclearROB selection: lowROB classification: lowROB missing: moderateROB mesure: moderateROB reporting: moderate Borthen (Controls unexposed, sick), 2010Borthen, 2010 3 1.89[0.82; 4.36]3723361%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 1.63[0.85; 3.14]544680.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick; 2: Controls unexposed, sick) ; 3: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.63[0.85; 3.14]544680%NAArtama (Controls unexposed, sick), 2013 Veiby (Controls unexposed, sick) b, 2013 Borthen (Controls unexposed, sick), 2010 3 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.63[0.85; 3.14]544680%NAArtama (Controls unexposed, sick), 2013 Veiby (Controls unexposed, sick) b, 2013 Borthen (Controls unexposed, sick), 2010 3 Tags Adjustment   - No  - No 1.57[0.75; 3.28]483360%NAVeiby (Controls unexposed, sick) b, 2013 Borthen (Controls unexposed, sick), 2010 2   - Yes  - Yes 1.89[0.46; 7.76]6132 -NAArtama (Controls unexposed, sick), 2013 1 All studiesAll studies 1.63[0.85; 3.14]544680%NAArtama (Controls unexposed, sick), 2013 Veiby (Controls unexposed, sick) b, 2013 Borthen (Controls unexposed, sick), 2010 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 6260, 5912, 6394

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.71[0.96; 3.02]10,7584680%NAArtama (Controls unexposed, disease free), 2013 Veiby (Controls unexposed, disease free) b, 2013 Borthen (Controls unexposed, disease free), 2010 3 unexposed, sick controlsunexposed, sick controls 1.63[0.85; 3.14]544680%NAArtama (Controls unexposed, sick), 2013 Veiby (Controls unexposed, sick) b, 2013 Borthen (Controls unexposed, sick), 2010 30.510.01.0