Lamotrigine (Epilepsy)

Spina bifida

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6329
R26066		 Veiby (Controls unexposed, sick), 2014 Spina bifida throughout pregnancy population based cohort retrospective unexposed, sick Adjustment: No 0.91 [0.05;17.62] C 0/593   3/3,773 3 593
ref
S8135
R24991		 Charlton, 2011 Spina bifida 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: No 1.85 [0.09;38.71] C 0/98   2/902 2 98
ref
Total 2 studies 1.28 [0.15;10.73] 5 691
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Veiby (Controls unexposed, sick), 2014Veiby, 2014 1 0.91[0.05; 17.62]359351%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: moderate Charlton, 2011Charlton, 2011 1.85[0.09; 38.71]29849%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.28[0.15; 10.73]56910.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.28[0.15; 10.73]56910%NAVeiby (Controls unexposed, sick), 2014 Charlton, 2011 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.28[0.15; 10.73]56910%NAVeiby (Controls unexposed, sick), 2014 Charlton, 2011 2 Tags Adjustment   - No  - No 1.28[0.15; 10.73]56910%NAVeiby (Controls unexposed, sick), 2014 Charlton, 2011 2 All studiesAll studies 1.28[0.15; 10.73]56910%NAVeiby (Controls unexposed, sick), 2014 Charlton, 2011 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.28[0.15; 10.73]56910%NAVeiby (Controls unexposed, sick), 2014 Charlton, 2011 20.510.01.0