Lamotrigine (Epilepsy)

Caesarean

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5912
R14919		 Artama (Controls unexposed, disease free), 2013 Caesarean section during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free excluded Adjustment: Yes 1.20 [0.81;1.77]
excluded (control group) 		32/173   114,791/721,948 114,823 173
ref
S5920
R15015		 Artama (Controls unexposed, sick), 2013 Caesarean section during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 0.93 [0.61;1.42] 32/173   331/1,800 363 173
ref
S6295
R17034		 Rihtman, 2013 Cesarean section at least 1st trimester excluded prospective cohort unexposed (general population or NOS) Adjustment: No 2.07 [0.54;7.92] C
excluded (exposition period) 		6/40   4/51 10 40
ref
S6260
R16720		 Borthen (Controls unexposed, disease free), 2010 Caesarean during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free excluded Adjustment: Yes 1.40 [1.00;1.90]
excluded (control group) 		44/233   51,806/362,302 51,850 233
ref
S6265
R16760		 Borthen (Controls unexposed, sick), 2010 Caesarean during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: No 1.05 [0.74;1.49] C 44/233   337/1,863 381 233
ref
Total 2 studies 1.00 [0.77;1.31] 744 406
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Artama (Controls unexposed, sick), 2013Artama, 2013 1 0.93[0.61; 1.42]36317341%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Borthen (Controls unexposed, sick), 2010Borthen, 2010 2 1.05[0.74; 1.49]38123359%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.00[0.77; 1.31]7444060.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick; 2: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.00[0.77; 1.31]7444060%NAArtama (Controls unexposed, sick), 2013 Borthen (Controls unexposed, sick), 2010 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.00[0.77; 1.31]7444060%NAArtama (Controls unexposed, sick), 2013 Borthen (Controls unexposed, sick), 2010 2 Tags Adjustment   - No  - No 1.05[0.74; 1.49]381233 -NABorthen (Controls unexposed, sick), 2010 1   - Yes  - Yes 0.93[0.61; 1.42]363173 -NAArtama (Controls unexposed, sick), 2013 1 All studiesAll studies 1.00[0.77; 1.31]7444060%NAArtama (Controls unexposed, sick), 2013 Borthen (Controls unexposed, sick), 2010 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 6260, 5912

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.32[1.03; 1.69]166,6734060%NAArtama (Controls unexposed, disease free), 2013 Borthen (Controls unexposed, disease free), 2010 2 unexposed, sick controlsunexposed, sick controls 1.00[0.77; 1.31]7444060%NAArtama (Controls unexposed, sick), 2013 Borthen (Controls unexposed, sick), 2010 20.510.01.0