Lamotrigine (Epilepsy)

Cleft lip with or without cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8119
R25703		 Holmes, 2008 Cleft lip with or without cleft palate isolated 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No 5.93 [1.46;24.07] C 2/684   102/206,224 104 684
ref
Total 1 studies 5.93 [1.46;24.07] 104 684
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Holmes, 2008Holmes, 2008 5.93[1.46; 24.07]1046840%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 5.93[1.46; 24.07]104684 -NAHolmes, 2008 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 5.93[1.46; 24.07]104684 -NAHolmes, 2008 1 Tags Adjustment   - No  - No 5.93[1.46; 24.07]104684 -NAHolmes, 2008 1 All studiesAll studies 5.93[1.46; 24.07]104684 -NAHolmes, 2008 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 5.93[1.46; 24.07]104684 -NAHolmes, 2008 10.510.01.0

Umbrella review (other published meta-analyses)

Published MATE95% CIn exposedkI2Control groupExposition period Veroniki (NMA)Veroniki (NMA) 1.21[0.45; 3.20]-whatever (meta-analysis)during pregnancy (anytime or not specified)studies7 metaPregmetaPreg 5.93[1.46; 24.07]NaN%684--Holmes, 2008 10.510.01.0