Lamotrigine (Epilepsy)

Cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8119
R24936		 Holmes, 2008 Cleft palate alone isolated 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No 21.00 [6.80;65.10] 3/684   43/206,224 46 684
ref
Total 1 studies 21.00 [6.79;64.98] 46 684
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Holmes, 2008Holmes, 2008 21.00[6.80; 65.10]466840%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: moderate0.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 21.00[6.79; 64.98]46684 -NAHolmes, 2008 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 21.00[6.79; 64.98]46684 -NAHolmes, 2008 1 Tags Adjustment   - No  - No 21.00[6.79; 64.98]46684 -NAHolmes, 2008 1 All studiesAll studies 21.00[6.79; 64.98]46684 -NAHolmes, 2008 10.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale21.00[6.79; 64.98]46684 -NAHolmes, 2008 10.510.01.0