Clonazepam (Epilepsy) updated on 02-10-2025

Cognitive developmental disorders/delay (> 6 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15241
R65327		 Dreier (Epilepsy) (Controls exposed to LTG), 2023 Intellectual disability - Corresponding ICD-10 F-chapter - Up to 22 years of age during pregnancy (anytime or not specified) population based cohort propective exposed to other treatment, sick excluded Adjustment: No 2.31 [0.90;5.95] C
excluded (control group) 		5/339   34/5,288 39 339
ref
S15234
R65328		 Dreier (Epilepsy) (Controls unexposed, sick), 2023 Intellectual disability - Corresponding ICD-10 F-chapter - Up to 22 years of age during pregnancy (anytime or not specified) population based cohort propective unexposed, sick Adjustment: Yes 0.55 [0.20;1.51] 5/339   184/22,203 189 339
ref
Total 1 studies 0.55 [0.20;1.51] 189 339
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Dreier (Epilepsy) (Controls unexposed, sick), 2023Dreier, 2023 1 0.55[0.20; 1.51]1893390%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Epilepsy) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.55[0.20; 1.51]189339 -NADreier (Epilepsy) (Controls unexposed, sick), 2023 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.55[0.20; 1.51]189339 -NADreier (Epilepsy) (Controls unexposed, sick), 2023 1 Tags Adjustment   - Yes  - Yes 0.55[0.20; 1.51]189339 -NADreier (Epilepsy) (Controls unexposed, sick), 2023 1 All studiesAll studies 0.55[0.20; 1.51]189339 -NADreier (Epilepsy) (Controls unexposed, sick), 2023 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 15241

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.55[0.20; 1.51]189339 -NADreier (Epilepsy) (Controls unexposed, sick), 2023 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.31[0.90; 5.95]39339 -NADreier (Epilepsy) (Controls exposed to LTG), 2023 10.510.01.0