Clonazepam (Epilepsy) updated on 02-10-2025

Caesarean

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5924
R15056		 Artama (Epilepsy) (Controls exposed to Lamotrigine, sick), 2013 Caesarean section during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.34 [0.04;2.69] C
excluded (control group) 		1/14   32/173 33 14
ref
S5905
R14848		 Artama (Epilepsy) (Controls unexposed, disease free), 2013 Caesarean section during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free excluded Adjustment: Yes 0.43 [0.06;3.27]
excluded (control group) 		1/14   114,791/721,948 114,792 14
ref
S5916
R14967		 Artama (Epilepsy) (Controls unexposed, sick), 2013 Caesarean section during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 0.37 [0.05;2.85] 1/14   331/1,800 332 14
ref
S8222
R25751		 Endo (Epilepsy) (Controls unexposed, disease free), 2004 Cesarean section throughout pregnancy retrospective cohort unexposed, disease free excluded Adjustment: No 7.93 [0.16;402.44] C
excluded (control group) 		1/1   74/656 75 1
ref
S8224
R25781		 Endo (Epilepsy) (Controls unexposed, sick), 2004 Cesarean section throughout pregnancy retrospective cohort unexposed, sick Adjustment: No no data 1/1   0/1 1 1
ref
Total 2 studies NaN [NaN;NaN] 333 15
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Artama (Epilepsy) (Controls unexposed, sick), 2013Artama, 2013 1 0.37[0.05; 2.85]33214NaN%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Endo (Epilepsy) (Controls unexposed, sick), 2004Endo, 2004 2 Out of scale-3.00[NaN; NaN]11NaN%ROB confusion: criticalROB selection: unclearROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = NaN% Out of scaleNaN[NaN; NaN]333150.02.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Epilepsy) (Controls unexposed, sick; 2: Epilepsy) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies Artama (Epilepsy) (Controls unexposed, sick), 2013 Endo (Epilepsy) (Controls unexposed, sick), 2004 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick Artama (Epilepsy) (Controls unexposed, sick), 2013 Endo (Epilepsy) (Controls unexposed, sick), 2004 2 Tags Adjustment   - No  - No Endo (Epilepsy) (Controls unexposed, sick), 2004 1   - Yes  - Yes 0.37[0.05; 2.79]33214 -NAArtama (Epilepsy) (Controls unexposed, sick), 2013 1 All studiesAll studies Artama (Epilepsy) (Controls unexposed, sick), 2013 Endo (Epilepsy) (Controls unexposed, sick), 2004 20.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 8222, 5924, 5905

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.11[0.08; 16.08]114,8671540%NAArtama (Epilepsy) (Controls unexposed, disease free), 2013 Endo (Epilepsy) (Controls unexposed, disease free), 2004 2 unexposed, sick controlsunexposed, sick controls Artama (Epilepsy) (Controls unexposed, sick), 2013 Endo (Epilepsy) (Controls unexposed, sick), 2004 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.34[0.04; 2.69]3314 -NAArtama (Epilepsy) (Controls exposed to Lamotrigine, sick), 2013 10.510.01.0