Topiramate (Epilepsy)

Early intrauterine death (< 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6251
R16644		 Arkilo (Topiramate), 2015 Spontaneous miscarriages during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick Adjustment: No 2.87 [0.09;91.05] C 0/2   2/24 2 2
ref
S6239
R16452		 Babic (Topiramate), 2014 Miscarriage (8–10 gestational week) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick Adjustment: No 45.00 [0.61;3297.13] C 1/2   0/8 1 2
ref
Total 2 studies 8.47 [0.57;125.19] 3 4
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Arkilo (Topiramate), 2015Arkilo, 2015 1 2.87[0.09; 91.05]2261%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Babic (Topiramate), 2014Babic, 2014 2 45.00[0.61; 3297.13]1239%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 8.47[0.57; 125.19]340.9100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Topiramate; 2: Topiramate;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 8.47[0.57; 125.19]340%NAArkilo (Topiramate), 2015 Babic (Topiramate), 2014 2 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 8.47[0.57; 125.19]340%NAArkilo (Topiramate), 2015 Babic (Topiramate), 2014 2 Tags Adjustment   - No  - No 8.47[0.57; 125.19]340%NAArkilo (Topiramate), 2015 Babic (Topiramate), 2014 2 All studiesAll studies 8.47[0.57; 125.19]340%NAArkilo (Topiramate), 2015 Babic (Topiramate), 2014 20.5100.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 8.47[0.57; 125.19]340%NAArkilo (Topiramate), 2015 Babic (Topiramate), 2014 20.510.01.0