Levetiracetam (Epilepsy)

Early intrauterine death (< 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S301
R16638		 Arkilo (Levetiracetam), 2015 Spontaneous miscarriages during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick Adjustment: No 0.41 [0.02;9.32] C 0/11   2/24 2 11
ref
S7815
R23209		 Tomson (Levetiracetam), 2015 Spontaneous abortions at least 1st trimester prospective cohort exposed to other treatment, sick Adjustment: No 1.11 [0.73;1.71] C 27/324   144/1,910 171 324
ref
S6240
R16454		 Babic (Levetiracetam), 2014 Miscarriage (8–10 gestational week) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick Adjustment: No 2.14 [0.03;131.94] C 0/4   0/8 0 4
ref
Total 3 studies 1.10 [0.72;1.68] 173 339
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Arkilo (Levetiracetam), 2015Arkilo, 2015 1 0.41[0.02; 9.32]2112%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Tomson (Levetiracetam), 2015Tomson, 2015 2 1.11[0.73; 1.71]17132497%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Babic (Levetiracetam), 2014Babic, 2014 3 2.14[0.03; 131.94]041%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 0% 1.10[0.72; 1.68]1733390.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Levetiracetam; 2: Levetiracetam; 3: Levetiracetam;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.10[0.72; 1.68]1733390%NAArkilo (Levetiracetam), 2015 Tomson (Levetiracetam), 2015 Babic (Levetiracetam), 2014 3 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 1.10[0.72; 1.68]1733390%NAArkilo (Levetiracetam), 2015 Tomson (Levetiracetam), 2015 Babic (Levetiracetam), 2014 3 Tags Adjustment   - No  - No 1.10[0.72; 1.68]1733390%NAArkilo (Levetiracetam), 2015 Tomson (Levetiracetam), 2015 Babic (Levetiracetam), 2014 3 All studiesAll studies 1.10[0.72; 1.68]1733390%NAArkilo (Levetiracetam), 2015 Tomson (Levetiracetam), 2015 Babic (Levetiracetam), 2014 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.10[0.72; 1.68]1733390%NAArkilo (Levetiracetam), 2015 Tomson (Levetiracetam), 2015 Babic (Levetiracetam), 2014 30.510.01.0