id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S12824 R48271 |
Thomas (Levetiracetam) (Controls exposed to Lamotrigine, sick), 2021 | Skeletal malformations | 1st trimester | prospective cohort | exposed to other treatment, sick excluded | Adjustment: No |
2.39 [0.11;50.76] C excluded (control group) |
2/106 0/50 | 2 | 106 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S12823 R48261 |
Thomas (Levetiracetam) (Controls unexposed, sick), 2021 | Skeletal malformations | 1st trimester | prospective cohort | unexposed, sick | Adjustment: No | 3.25 [0.45;23.36] C | 2/106 2/340 | 4 | 106 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S6063 R15771 |
Morrow (Levetiracetam) (Controls exposed to Lamotrigine, sick), 2006 | Skeletal abnormalities | 1st trimester | prospective cohort | exposed to other treatment, sick | Adjustment: No | 6.00 [0.28;128.72] C | 0/22 2/647 | 2 | 22 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 2 studies | 3.89 [0.74;20.42] | 6 | 128 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Levetiracetam) (Controls unexposed, sick; 2: Levetiracetam) (Controls exposed to Lamotrigine, sick;
Funnel plot not drawn. Less than 3 points.
Asymetry test p-value = NaN (by Egger's regression)
not enought points
Funnel plot not drawn. Less than 3 points.
excluded 12824