Gabapentin (Epilepsy)

Neuro-developmental disorders (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6252
R16652		 Arkilo (Gabapentin), 2015 Abnormal development (At 2 years of age, assessed by developmental specialists) during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick Adjustment: No 8.60 [0.14;536.34] C 0/1   2/24 2 1
ref
S6682
R18547		 Dean (Gabapentin), 2002 Developmental delay at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 7.44 [0.13;423.73] C 0/1   4/38 4 1
ref
Total 2 studies 7.99 [0.44;143.69] 6 2
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Arkilo (Gabapentin), 2015Arkilo, 2015 1 8.60[0.14; 536.34]2149%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Dean (Gabapentin), 2002Dean, 2002 2 7.44[0.13; 423.73]4151%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 7.99[0.44; 143.69]620.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Gabapentin; 2: Gabapentin;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 7.99[0.44; 143.69]620%NAArkilo (Gabapentin), 2015 Dean (Gabapentin), 2002 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 7.44[0.13; 423.73]41 -NADean (Gabapentin), 2002 1 exposed to other treatment, sickexposed to other treatment, sick 8.60[0.14; 536.34]21 -NAArkilo (Gabapentin), 2015 1 Tags Adjustment   - No  - No 7.99[0.44; 143.69]620%NAArkilo (Gabapentin), 2015 Dean (Gabapentin), 2002 2 All studiesAll studies 7.99[0.44; 143.69]620%NAArkilo (Gabapentin), 2015 Dean (Gabapentin), 2002 20.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 7.44[0.13; 423.73]41 -NADean (Gabapentin), 2002 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 8.60[0.14; 536.34]21 -NAArkilo (Gabapentin), 2015 10.510.01.0