id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S10732 R39685 |
De Jonge (Valproate), 2013 | Genital malformations | 1st trimester | case control | unexposed (general population or NOS) | Adjustment: No Monotherapy: no or not specified | 1.31 [0.08;21.42] C | 0/35 314/29,502 | 314 | 35 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S6099 R15909 |
Artama (Valproate), 2005 | Genital organs | 1st trimester | retrospective cohort (registry) | unexposed, sick | Adjustment: No | 3.62 [1.04;12.60] C | 5/263 5/939 | 10 | 263 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 2 studies | 3.06 [0.98;9.55] | 324 | 298 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Valproate; 2: Valproate;
Funnel plot not drawn. Less than 3 points.
Asymetry test p-value = NaN (by Egger's regression)
not enought points
Funnel plot not drawn. Less than 3 points.
excluded