Valproate (Epilepsy)

Assisted deliveries (forceps, vacuum, ...)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6261
R16731		 Borthen (Valproate) (Controls exposed to Lamotrigine, sick), 2010 Delivery Cephalic vaginal with forceps or vacuum during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.73 [0.41;1.32] C
excluded (control group) 		21/215   30/233 51 215
ref
S5684
R16675		 Borthen (Valproate) (Controls unexposed, disease free), 2010 Delivery Cephalic vaginal with forceps or vacuum during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free excluded Adjustment: Yes 1.40 [0.90;2.20]
excluded (control group) 		21/215   28,546/362,302 28,567 215
ref
S6263
R16747		 Borthen (Valproate) (Controls unexposed, sick), 2010 Delivery Cephalic vaginal with forceps or vacuum during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: No 1.19 [0.74;1.93] C 21/215   155/1,863 176 215
ref
S8221
R25737		 Endo (Valproate) (Controls unexposed, disease free), 2004 Forceps deliveries at least 1st trimester retrospective cohort unexposed, disease free excluded Adjustment: No 2.84 [0.31;25.91] C
excluded (control group) 		1/5   53/656 54 5
ref
S8311
R26294		 Endo (Valproate) (Controls unexposed, sick), 2004 Forceps deliveries throughout pregnancy retrospective cohort unexposed, sick Adjustment: No 0.43 [0.01;33.60] C 1/5   0/1 1 5
ref
Total 2 studies 1.18 [0.73;1.90] 177 220
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Borthen (Valproate) (Controls unexposed, sick), 2010Borthen, 2010 1 1.19[0.74; 1.93]17621599%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Endo (Valproate) (Controls unexposed, sick), 2004Endo, 2004 2 0.43[0.01; 33.60]151%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.18[0.73; 1.90]1772200.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Valproate) (Controls unexposed, sick; 2: Valproate) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.18[0.73; 1.90]1772200%NABorthen (Valproate) (Controls unexposed, sick), 2010 Endo (Valproate) (Controls unexposed, sick), 2004 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.18[0.73; 1.90]1772200%NABorthen (Valproate) (Controls unexposed, sick), 2010 Endo (Valproate) (Controls unexposed, sick), 2004 2 Tags Adjustment   - No  - No 1.18[0.73; 1.90]1772200%NABorthen (Valproate) (Controls unexposed, sick), 2010 Endo (Valproate) (Controls unexposed, sick), 2004 2 All studiesAll studies 1.18[0.73; 1.90]1772200%NABorthen (Valproate) (Controls unexposed, sick), 2010 Endo (Valproate) (Controls unexposed, sick), 2004 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 8221, 6261, 5684

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.40[0.90; 2.19]28,567215 -NABorthen (Valproate) (Controls unexposed, disease free), 2010 1 unexposed, sick controlsunexposed, sick controls 1.18[0.73; 1.90]1772200%NABorthen (Valproate) (Controls unexposed, sick), 2010 Endo (Valproate) (Controls unexposed, sick), 2004 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.73[0.41; 1.32]51215 -NABorthen (Valproate) (Controls exposed to Lamotrigine, sick), 2010 10.510.01.0