id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S6168 R16233 |
Viinikainen (Valproate) (Controls unexposed, sick) a, 2006 | Cleft lip | throughout pregnancy | prospective cohort | unexposed, sick | Adjustment: No | 1.87 [0.04;96.99] C | 0/28 0/52 | 0 | 28 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S6099 R15907 |
Artama (Valproate), 2005 | Cleft lip/ cleft palate | 1st trimester | retrospective cohort (registry) | unexposed, sick | Adjustment: No | 9.08 [1.75;47.07] C | 5/263 2/939 | 7 | 263 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 2 studies | 7.19 [1.57;32.82] | 7 | 291 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Valproate) (Controls unexposed, sick) ; 2: Valproate;
Funnel plot not drawn. Less than 3 points.
Asymetry test p-value = NaN (by Egger's regression)
not enought points
Funnel plot not drawn. Less than 3 points.
excluded