id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S15877 R65488 |
Dreier (Valproate) (Epilepsy) (Controls exposed to LTG), 2023 | Autism spectrum disorder - Corresponding ICD-10 F-chapter - Up to 22 years of age | during pregnancy (anytime or not specified) | population based cohort propective | exposed to other treatment, sick excluded | Adjustment: No |
4.08 [2.96;5.64] C excluded (control group) |
93/1,952 64/5,288 | 157 | 1,952 |
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S15878 R65477 |
Dreier (Valproate) (Epilepsy) (Controls unexposed, sick), 2023 | Autism spectrum disorder - Corresponding ICD-10 F-chapter - Up to 22 years of age | during pregnancy (anytime or not specified) | population based cohort propective | unexposed, sick | Adjustment: Yes | 2.45 [1.84;3.26] | 93/1,952 323/22,203 | 416 | 1,952 |
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S10070 R36645 |
Coste (Valproate) (Controls exposed to Lamotrigine, sick), 2020 | Diagnosis Pervasive developmental disorders (F84) (mean age of 3.7 years old) | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | exposed to other treatment, sick excluded | Adjustment: Yes |
4.70 [1.90;11.40] excluded (control group) |
17/991 7/2,108 | 24 | 991 |
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S7799 R23030 |
Coste (Valproate) (Controls unexposed, NOS), 2020 | Diagnosis Pervasive developmental disorders (F84) (mean age of 3.6 years old) | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: Yes | 4.60 [2.90;7.50] | 17/991 4,280/1,710,441 | 4,297 | 991 |
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S8008 R24384 |
Wiggs (Valproate), 2020 | Austism Spectrum Disorder (after 2 years of age) | at least 1st trimester | population based cohort retrospective | unexposed, sick | Adjustment: Yes | 2.30 [1.53;3.47] | -/- -/11,298 | - | - |
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S7508 R22469 |
Huber-Mollema (Valproate), 2019 | Diagnosis of autism spectrum disorder | throughout pregnancy | prospective cohort | exposed to other treatment, sick | Adjustment: No | 2.74 [0.57;13.12] C | 3/26 4/88 | 7 | 26 |
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S5549 R16273 |
Wood (Valproate), 2015 | Score >30 (CARS) | during pregnancy (anytime or not specified) | prospective cohort | exposed to other treatment, sick | Adjustment: No | 1.04 [0.04;28.06] C | 1/26 0/9 | 1 | 26 |
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S6662 R35210 |
Bromley (Valproate) (Controls exposed to Lamotrigine, sick), 2013 | Autistic Spectrum Disorders (at 6 years old) | during pregnancy (anytime or not specified) | prospective cohort | exposed to other treatment, sick excluded | Adjustment: No |
2.52 [0.27;23.69] C excluded (control group) |
4/50 1/30 | 5 | 50 |
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S6659 R35211 |
Bromley (Valproate) (Controls unexposed, disease free), 2013 | Autistic Spectrum Disorders (at 6 years old) | during pregnancy (anytime or not specified) | prospective cohort | unexposed, disease free excluded | Adjustment: No |
4.57 [1.10;18.93] C excluded (control group) |
4/50 4/214 | 8 | 50 |
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S6602 R35212 |
Bromley (Valproate) (Controls unexposed, sick), 2013 | Autistic Spectrum Disorders (at 6 years old) | during pregnancy (anytime or not specified) | prospective cohort | unexposed, sick | Adjustment: No | 5.04 [0.26;97.51] C | 4/50 0/26 | 4 | 50 |
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S7175 R27086 |
Adab (Valproate), 2004 | Asperger’s syndrome | during pregnancy (anytime or not specified) | retrospective cohort | unexposed, sick | Adjustment: No | 4.90 [0.20;122.25] C | 1/63 0/101 | 1 | 63 |
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Total | 7 studies | 2.77 [2.19;3.50] | 4,726 | 3,108 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Valproate) (Epilepsy) (Controls unexposed, sick; 2: Valproate) (Controls unexposed, NOS; 3: Valproate; 4: Valproate; 5: Valproate; 6: Valproate) (Controls unexposed, sick; 7: Valproate;
Asymetry test p-value = 0.7054 (by Egger's regression)
slope=0.9502 (0.1801); intercept=0.2580 (0.6445); t=0.4003; p=0.7054
excluded 6662, 6659, 10070, 15877