Phenytoin (Epilepsy)

Eye defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6098
R15888		 Artama (Phenytoin), 2005 Eye 1st trimester retrospective cohort (registry) unexposed, sick Adjustment: No 8.33 [0.33;208.00] C 0/38   1/939 1 38
ref
S6680
R18525		 Dean (Phenytoin), 2002 Any eye disorder at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 1.07 [0.27;4.25] C 4/24   6/38 10 24
ref
Total 2 studies 1.75 [0.31;9.77] 11 62
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Artama (Phenytoin), 2005Artama, 2005 1 8.33[0.33; 208.00]13824%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Dean (Phenytoin), 2002Dean, 2002 2 1.07[0.27; 4.25]102476%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 24% 1.75[0.31; 9.77]11620.520.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenytoin; 2: Phenytoin;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.75[0.31; 9.77]116224%NAArtama (Phenytoin), 2005 Dean (Phenytoin), 2002 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.75[0.31; 9.77]116224%NAArtama (Phenytoin), 2005 Dean (Phenytoin), 2002 2 Tags Adjustment   - No  - No 1.75[0.31; 9.77]116224%NAArtama (Phenytoin), 2005 Dean (Phenytoin), 2002 2 All studiesAll studies 1.75[0.31; 9.77]116224%NAArtama (Phenytoin), 2005 Dean (Phenytoin), 2002 20.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.75[0.31; 9.77]116224%NAArtama (Phenytoin), 2005 Dean (Phenytoin), 2002 20.510.01.0