Phenytoin (Epilepsy)

Minor congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6680
R18514		 Dean (Phenytoin), 2002 Minor congenital malformations at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 3.71 [1.07;12.90] C 9/25   5/38 14 25
ref
S6303
R17073		 Wide (Phenytoin), 2000 Minor anomalies throughout pregnancy prospective cohort unexposed (general population or NOS) Adjustment: No Matched 0.80 [0.22;2.98] 5/21   6/19 11 21
ref
S7273
R21042		 Battino (Phenytoin), 1992 Minor anomalies 1st trimester prospective cohort unexposed, sick Adjustment: No 3.40 [0.16;70.12] C 4/27   0/9 4 27
ref
Total 3 studies 1.90 [0.62;5.84] 29 73
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Dean (Phenytoin), 2002Dean, 2002 1 3.71[1.07; 12.90]142545%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Wide (Phenytoin), 2000Wide, 2000 2 0.80[0.22; 2.98]112143%ROB confusion: criticalROB selection: moderateROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Battino (Phenytoin), 1992Battino, 1992 3 3.40[0.16; 70.12]42712%ROB confusion: criticalROB selection: moderateROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 32% 1.90[0.62; 5.84]29730.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenytoin; 2: Phenytoin; 3: Phenytoin;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.90[0.62; 5.84]297332%NADean (Phenytoin), 2002 Wide (Phenytoin), 2000 Battino (Phenytoin), 1992 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.80[0.22; 2.94]1121 -NAWide (Phenytoin), 2000 1 unexposed, sickunexposed, sick 3.67[1.16; 11.60]18520%NADean (Phenytoin), 2002 Battino (Phenytoin), 1992 2 Tags Adjustment   - No  - No 1.90[0.62; 5.84]297332%NADean (Phenytoin), 2002 Wide (Phenytoin), 2000 Battino (Phenytoin), 1992 3 MatchedMatched 0.80[0.22; 2.94]1121 -NAWide (Phenytoin), 2000 1 All studiesAll studies 1.90[0.62; 5.84]297332%NADean (Phenytoin), 2002 Wide (Phenytoin), 2000 Battino (Phenytoin), 1992 30.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.80[0.22; 2.94]1121 -NAWide (Phenytoin), 2000 1 unexposed, sick controlsunexposed, sick controls 3.67[1.16; 11.60]18520%NADean (Phenytoin), 2002 Battino (Phenytoin), 1992 20.510.01.0