id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S7303 R53610 |
Meador (Phenytoin), 2013 | the Bayley Scales of Infant Development (BSID) <85 (at 2 years old) | during pregnancy (anytime or not specified) | prospective cohort | exposed to other treatment, sick | Adjustment: Yes | 3.52 [1.44;8.60] C | 17/42 11/68 | 28 | 42 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S6584 R53611 |
Thomas b (Phenytoin), 2008 | Impaired Mental Development Quotient < 84 (The Developmental Assessment Scale (DAS II)) | during pregnancy (anytime or not specified) | prospective cohort | unexposed, sick | Adjustment: No | 1.34 [0.47;3.88] C | 11/29 10/32 | 21 | 29 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S6303 R53612 |
Wide (Phenytoin), 2000 | Griffiths test total score (SD estimated) | throughout pregnancy | prospective cohort | unexposed (general population or NOS) | Adjustment: No extrapolated (cont. endpoint) Matched | 0.82 [0.26;2.52] | -/21 -/21 | - | 21 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S368 R53609 |
Kelly (Phenytoin), 1984 | Delayed development | during pregnancy (anytime or not specified) | prospective cohort | unexposed, sick | Adjustment: No | 0.06 [0.00;1.26] C | 0/41 3/21 | 3 | 41 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 4 studies | 1.17 [0.40;3.49] | 52 | 133 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Phenytoin; 2: Phenytoin; 3: Phenytoin; 4: Phenytoin;
Asymetry test p-value = NaN (by Egger's regression)
not enought points
excluded