Phenytoin (Epilepsy) - Medication and Pregnancy KB

Phenytoin (Epilepsy)

Feeding difficulty

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S6932 R21686	Yerby (Phenytoin), 1992	Feeding difficulties	during pregnancy (anytime or not specified)	prospective cohort	unexposed, disease free	Adjustment: No	4.09 [0.24;70.66] ^C	1/12 1/46	2	12		ref
S341 R18425	D'Souza (Phenytoin) (Controls unexposed, disease free), 1991	Feeding difficulty (tube fed)	throughout pregnancy	prospective cohort	unexposed, disease free excluded	Adjustment: No Matched	2.86 [0.06;148.65] ^C excluded (control group)	0/22 0/62	0	22		ref
S6690 R18739	D'Souza (Phenytoin) (Controls unexposed, sick), 1991	Feeding difficulty (tube fed)	throughout pregnancy	prospective cohort	unexposed, sick	Adjustment: No	0.35 [0.01;19.18] ^C	0/22 0/8	0	22		ref
					Total	2 studies	1.79 [0.18;18.25]		2	34
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Phenytoin; 2: Phenytoin) (Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 341