Phenytoin (Epilepsy)

Perinatal death

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5922
R15041		 Artama (Phenytoin) (Controls exposed to Lamotrigine, sick), 2013 Perinatal death (stillbirth or early neonatal death (0–6 days of age)) during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 6.76 [0.13;348.53] C
excluded (control group) 		0/26   0/173 0 26
ref
S305
R14812		 Artama (Phenytoin) (Controls unexposed, disease free), 2013 Perinatal death (stillbirth or early neonatal death (0–6 days of age)) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free excluded Adjustment: No 3.98 [0.24;65.31] C
excluded (control group) 		0/26   3,543/721,948 3,543 26
ref
S5914
R14945		 Artama (Phenytoin) (Controls unexposed, sick), 2013 Perinatal death (stillbirth or early neonatal death (0–6 days of age)) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: No 3.34 [0.19;58.58] C 0/26   10/1,800 10 26
ref
S7173
R20107		 Canger (Phenytoin), 1999 Perinatal deaths (NOS) 1st trimester prospective cohort unexposed, sick Adjustment: No 0.80 [0.02;41.97] C 0/31   0/25 0 31
ref
Total 2 studies 2.05 [0.20;20.82] 10 57
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Artama (Phenytoin) (Controls unexposed, sick), 2013Artama, 2013 1 3.34[0.19; 58.58]102666%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Canger (Phenytoin), 1999Canger, 1999 2 0.80[0.02; 41.97]03134%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 2.05[0.20; 20.82]10570.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenytoin) (Controls unexposed, sick; 2: Phenytoin;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.05[0.20; 20.82]10570%NAArtama (Phenytoin) (Controls unexposed, sick), 2013 Canger (Phenytoin), 1999 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.05[0.20; 20.82]10570%NAArtama (Phenytoin) (Controls unexposed, sick), 2013 Canger (Phenytoin), 1999 2 Tags Adjustment   - No  - No 2.05[0.20; 20.82]10570%NAArtama (Phenytoin) (Controls unexposed, sick), 2013 Canger (Phenytoin), 1999 2 All studiesAll studies 2.05[0.20; 20.82]10570%NAArtama (Phenytoin) (Controls unexposed, sick), 2013 Canger (Phenytoin), 1999 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 5922, 305

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.98[0.24; 65.31]3,54326 -NAArtama (Phenytoin) (Controls unexposed, disease free), 2013 1 unexposed, sick controlsunexposed, sick controls 2.05[0.20; 20.82]10570%NAArtama (Phenytoin) (Controls unexposed, sick), 2013 Canger (Phenytoin), 1999 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 6.76[0.13; 348.53]-26 -NAArtama (Phenytoin) (Controls exposed to Lamotrigine, sick), 2013 10.510.01.0