id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S7661 R22669 |
Tomson (Phenytoin), 2018 | Hypospadias | at least 1st trimester | prospective cohort | exposed to other treatment, sick | Adjustment: No | 1.55 [0.09;27.66] C | 0/125 6/2,514 | 6 | 125 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S5878 R23783 |
Hernández-Díaz (Phenytoin) (Controls exposed to Lamotrigine, sick), 2012 | Hypospadias | 1st trimester | prospective cohort | exposed to other treatment, sick | Adjustment: No Controls: mixed indications | 3.76 [0.07;189.69] C | 0/416 0/1,562 | 0 | 416 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S6501 R17867 |
Bànhidy (Phenytoin), 2011 | Hypospadias | throughout pregnancy | case control | unexposed, sick | Adjustment: No Matched | 0.35 [0.05;2.46] C | 2/21 3/13 | 5 | 21 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S319 R15724 |
Morrow (Phenytoin) (Controls exposed to Lamotrigine, sick), 2006 | Hypospadias/genitourinary tract defects | 1st trimester | prospective cohort | exposed to other treatment, sick | Adjustment: No | 0.60 [0.03;10.83] C | 0/82 6/647 | 6 | 82 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S341 R18233 |
D'Souza (Phenytoin) (Controls unexposed, disease free), 1991 | Hypospadias | throughout pregnancy | prospective cohort | unexposed, disease free excluded | Adjustment: No Matched |
9.00 [0.35;229.68] C excluded (control group) |
1/22 0/62 | 1 | 22 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S6690 R18733 |
D'Souza (Phenytoin) (Controls unexposed, sick), 1991 | Hypospadias | throughout pregnancy | prospective cohort | unexposed, sick | Adjustment: No | 1.10 [0.04;30.00] C | 1/22 0/8 | 1 | 22 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 5 studies | 0.75 [0.22;2.57] | 18 | 666 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Phenytoin; 2: Phenytoin) (Controls exposed to Lamotrigine, sick; 3: Phenytoin; 4: Phenytoin) (Controls exposed to Lamotrigine, sick; 5: Phenytoin) (Controls unexposed, sick;
Asymetry test p-value = 0.0303 (by Egger's regression)
slope=-3.1707 (0.7657); intercept=2.1169 (0.5456); t=3.8797; p=0.0303
excluded 341