id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S9842 R35277 |
Vajda (Phenytoin) (Controls unexposed, sick), 2013 | Palate/lip malformation | at least 1st trimester | prospective cohort | unexposed, sick | Adjustment: No | 3.37 [0.07;172.23] C | 0/44 0/147 | 0 | 44 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S6501 R17863 |
Bànhidy (Phenytoin), 2011 | Cleft lip with or without cleft palate | throughout pregnancy | case control | unexposed, sick | Adjustment: No Matched | 0.57 [0.01;30.76] C | 1/20 0/10 | 1 | 20 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S6173 R21995 |
Viinikainen (Phenytoin) (Controls unexposed, sick) a, 2006 | Cleft lip | throughout pregnancy | prospective cohort | unexposed, sick | Adjustment: No | 34.33 [0.49;2389.88] C | 0/2 0/52 | 0 | 2 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S6098 R15891 |
Artama (Phenytoin), 2005 | Cleft lip/ cleft palate | 1st trimester | retrospective cohort (registry) | unexposed, sick | Adjustment: No | 4.99 [0.24;105.88] C | 0/38 2/939 | 2 | 38 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S379 R18063 |
Lowe (Phenytoin) (Controls unexposed, disease free), 1973 | Cleft lip and/or cleft palate | 1st trimester | population based cohort retrospective | unexposed, disease free excluded | Adjustment: No |
37.53 [2.14;659.17] C excluded (control group) |
0/9 49/31,632 | 49 | 9 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S6588 R18069 |
Lowe (Phenytoin) (Controls unexposed, sick), 1973 | Cleft lip and/or cleft palate | 1st trimester | population based cohort retrospective | unexposed, sick | Adjustment: No | 13.00 [0.24;696.83] C | 0/9 0/111 | 0 | 9 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 5 studies | 5.07 [0.94;27.30] | 3 | 113 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Phenytoin) (Controls unexposed, sick; 2: Phenytoin; 3: Phenytoin) (Controls unexposed, sick) ; 4: Phenytoin; 5: Phenytoin) (Controls unexposed, sick;
Asymetry test p-value = 0.8213 (by Egger's regression)
slope=0.1701 (5.9478); intercept=0.7631 (3.0983); t=0.2463; p=0.8213
excluded 379