Phenytoin (Epilepsy)

Cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6501
R17864		 Bànhidy (Phenytoin), 2011 Cleft palate throughout pregnancy case control unexposed, sick Adjustment: No Matched 0.57 [0.01;30.76] C 1/20   0/10 1 20
ref
S6173
R21993		 Viinikainen (Phenytoin) (Controls unexposed, sick) a, 2006 Cleft palate throughout pregnancy prospective cohort unexposed, sick Adjustment: No 34.33 [0.49;2389.88] C 0/2   0/52 0 2
ref
Total 2 studies 4.13 [0.07;229.95] 1 22
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bànhidy (Phenytoin), 2011Bànhidy, 2011 1 0.57[0.01; 30.76]12052%ROB confusion: criticalROB selection: criticalROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Viinikainen (Phenytoin) (Controls unexposed, sick) a, 2006Viinikainen, 2006 2 34.33[0.49; 2389.88]0248%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 48% 4.13[0.07; 229.95]1220.2100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenytoin; 2: Phenytoin) (Controls unexposed, sick) ;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 34.33[0.49; 2389.88]-2 -NAViinikainen (Phenytoin) (Controls unexposed, sick) a, 2006 1 case control studiescase control studies 0.57[0.01; 30.76]120 -NABànhidy (Phenytoin), 2011 1 Type of controls unexposed, sickunexposed, sick 4.13[0.07; 229.95]12248%NABànhidy (Phenytoin), 2011 Viinikainen (Phenytoin) (Controls unexposed, sick) a, 2006 2 Tags Adjustment   - No  - No 4.13[0.07; 229.95]12248%NABànhidy (Phenytoin), 2011 Viinikainen (Phenytoin) (Controls unexposed, sick) a, 2006 2 MatchedMatched 0.57[0.01; 30.76]120 -NABànhidy (Phenytoin), 2011 1 All studiesAll studies 4.13[0.07; 229.95]12248%NABànhidy (Phenytoin), 2011 Viinikainen (Phenytoin) (Controls unexposed, sick) a, 2006 20.2100.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 4.13[0.07; 229.95]12248%NABànhidy (Phenytoin), 2011 Viinikainen (Phenytoin) (Controls unexposed, sick) a, 2006 20.510.01.0