Carbamazepine (Epilepsy)

Low birth weight (< 2500g)

id	Study   Auto Coste (Carbamazepine), 2020Artama (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2013Artama (Carbamazepine) (Controls unexposed, disease free), 2013Artama (Carbamazepine) (Controls unexposed, sick), 2013Veiby (Carbamazepine) (Controls exposed to Lamotrigine, sick) b, 2013Veiby (Carbamazepine) (Controls unexposed, disease free) b, 2013Veiby (Carbamazepine) (Controls unexposed, sick) b, 2013Kini (Carbamazepine) (Controls unexposed, sick), 2006	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S10075 R36693	Coste (Carbamazepine), 2020	Weight at birth <2500 g	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	exposed to other treatment, sick	Adjustment: No	1.34 [0.75;2.37] C	14/176   128/2,108	142	176		ref
S5925 R15072	Artama (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2013	Low birth weight (< 2500g)	during pregnancy (anytime or not specified)	population based cohort retrospective	exposed to other treatment, sick excluded	Adjustment: No	1.38 [0.58;3.27] C excluded (control group)	51/1,077   6/173	57	1,077		ref
S5909 R14887	Artama (Carbamazepine) (Controls unexposed, disease free), 2013	Low birth weight (< 2500g)	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed, disease free excluded	Adjustment: Yes	1.63 [1.23;2.17] excluded (control group)	51/1,077   21,546/719,509	21,597	1,077		ref
S5917 R14983	Artama (Carbamazepine) (Controls unexposed, sick), 2013	Low birth weight (< 2500g)	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed, sick	Adjustment: Yes	1.31 [0.89;1.92]	51/1,077   65/1,793	116	1,077		ref
S6356 R21028	Veiby (Carbamazepine) (Controls exposed to Lamotrigine, sick) b, 2013	Low birth weight (< 2500 grams)	during pregnancy (anytime or not specified)	prospective cohort	exposed to other treatment, sick excluded	Adjustment: No	1.30 [0.38;4.46] C excluded (control group)	5/67   6/103	11	67		ref
S6354 R17338	Veiby (Carbamazepine) (Controls unexposed, disease free) b, 2013	Low birth weight (< 2500 grams)	during pregnancy (anytime or not specified)	prospective cohort	unexposed, disease free excluded	Adjustment: Yes	1.80 [0.70;4.40] excluded (control group)	5/67   5,024/106,899	5,029	67		ref
S6355 R17334	Veiby (Carbamazepine) (Controls unexposed, sick) b, 2013	Low birth weight (< 2500 grams)	during pregnancy (anytime or not specified)	prospective cohort	unexposed, sick	Adjustment: No	1.86 [0.66;5.27] C	5/67   16/386	21	67		ref
S7181 R20253	Kini (Carbamazepine) (Controls unexposed, sick), 2006	Birth weight <2500 g	during pregnancy (anytime or not specified)	retrospective cohort	unexposed, sick	Adjustment: No	0.27 [0.07;1.00] C	3/94   11/101	14	94		ref
					Total	4 studies	1.16 [0.71;1.92]		293	1,414
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 5925, 5909, 6356, 6354