Carbamazepine (Epilepsy)

Child/Infant death (> 28 days of life)

id	Study   Auto Artama (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2013Artama (Carbamazepine) (Controls unexposed, disease free), 2013Artama (Carbamazepine) (Controls unexposed, sick), 2013Van der Pol (Carbamazepine) (Controls unexposed, disease free), 1991Van der Pol (Carbamazepine) (Controls unexposed, sick), 1991	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S5925 R15075	Artama (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2013	Infant death (0–364 days of age)	during pregnancy (anytime or not specified)	population based cohort retrospective	exposed to other treatment, sick excluded	Adjustment: No	0.96 [0.12;8.05] C excluded (control group)	6/1,077   1/173	7	1,077		ref
S5909 R14890	Artama (Carbamazepine) (Controls unexposed, disease free), 2013	Infant death (0–364 days of age)	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed, disease free excluded	Adjustment: Yes	1.94 [0.86;4.39] excluded (control group)	6/1,077   2,048/719,509	2,054	1,077		ref
S5917 R14986	Artama (Carbamazepine) (Controls unexposed, sick), 2013	Infant death (0–364 days of age)	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed, sick	Adjustment: Yes	2.70 [0.72;10.07]	6/1,077   5/1,793	11	1,077		ref
S6823 R19281	Van der Pol (Carbamazepine) (Controls unexposed, disease free), 1991	Death (from 6 to 13 years)	throughout pregnancy	prospective cohort	unexposed, disease free excluded	Adjustment: No Matched	5.26 [0.10;278.85] C excluded (control group)	0/12   0/61	0	12		ref
S6825 R19331	Van der Pol (Carbamazepine) (Controls unexposed, sick), 1991	Death (from 6 to 13 years)	throughout pregnancy	prospective cohort	unexposed, sick	Adjustment: No	0.65 [0.02;17.31] C	0/12   1/24	1	12		ref
					Total	2 studies	2.22 [0.65;7.53]		12	1,089
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 6823, 5925, 5909