Carbamazepine (Epilepsy) - Medication and Pregnancy KB

Carbamazepine (Epilepsy)

Low Apgar score (< 7) (at 5 min)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S5925 R15067	Artama (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2013	5-min Apgar <7	3rd trimester	population based cohort retrospective	exposed to other treatment, sick excluded	Adjustment: No	0.35 [0.06;2.12] ^C excluded (control group)	2/248 3/132	5	248		ref
S5909 R14882	Artama (Carbamazepine) (Controls unexposed, disease free), 2013	5-min Apgar <7	3rd trimester	population based cohort retrospective	unexposed, disease free excluded	Adjustment: Yes	0.85 [0.21;3.42] excluded (control group)	2/248 3,014/269,151	3,016	248		ref
S5917 R14978	Artama (Carbamazepine) (Controls unexposed, sick), 2013	5-min Apgar <7	3rd trimester	population based cohort retrospective	unexposed, sick	Adjustment: Yes	1.08 [0.20;5.15]	2/248 3/652	5	248		ref
S6356 R21026	Veiby (Carbamazepine) (Controls exposed to Lamotrigine, sick) b, 2013	Low Apgar score (< 7 at 5 min)	during pregnancy (anytime or not specified)	prospective cohort	exposed to other treatment, sick excluded	Adjustment: No	0.30 [0.01;6.40] ^C excluded (control group)	0/67 2/103	2	67		ref
S6354 R17336	Veiby (Carbamazepine) (Controls unexposed, disease free) b, 2013	Low Apgar score (< 7 at 5 min)	during pregnancy (anytime or not specified)	prospective cohort	unexposed, disease free excluded	Adjustment: No	0.46 [0.03;7.47] ^C excluded (control group)	0/67 1,710/106,899	1,710	67		ref
S6355 R17332	Veiby (Carbamazepine) (Controls unexposed, sick) b, 2013	Low Apgar score (< 7 at 5 min)	during pregnancy (anytime or not specified)	prospective cohort	unexposed, sick	Adjustment: No	0.30 [0.02;5.18] ^C	0/67 9/386	9	67		ref
S5511 R17500	Pennell (Carbamazepine), 2012	Apgar score (at 5 minutes < 7)	during pregnancy (anytime or not specified)	prospective cohort	exposed to other treatment, sick	Adjustment: No	3.23 [0.13;80.44] ^C	1/91 0/97	1	91		ref
S6262 R16742	Borthen (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2010	Apgar < 7 after 5 minutes	during pregnancy (anytime or not specified)	population based cohort retrospective	exposed to other treatment, sick excluded	Adjustment: No	0.94 [0.36;2.46] ^C excluded (control group)	11/388 7/233	18	388		ref
S6259 R16718	Borthen (Carbamazepine) (Controls unexposed, disease free), 2010	Apgar < 7 after 5 minutes	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed, disease free excluded	Adjustment: Yes	1.70 [0.90;3.10] excluded (control group)	11/388 6,022/362,302	6,033	388		ref
S6264 R16758	Borthen (Carbamazepine) (Controls unexposed, sick), 2010	Apgar < 7 after 5 minutes	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed, sick	Adjustment: No	1.78 [0.89;3.59] ^C	11/388 30/1,863	41	388		ref
					Total	4 studies	1.56 [0.84;2.89]		56	794
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Carbamazepine) (Controls unexposed, sick; 2: Carbamazepine) (Controls unexposed, sick) ; 3: Carbamazepine; 4: Carbamazepine) (Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Sub-groups analysis using all included studies

excluded 6262, 6259, 5925, 5909, 6356, 6354