Carbamazepine (Epilepsy)

Club foot / Talipes equinovarus

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5483
R15649		 Bànhidy (Carbamazepine), 2011 Clubfoot throughout pregnancy case control unexposed, sick Adjustment: No Matched 3.32 [0.12;91.61] C 2/12   0/10 2 12
ref
S6823
R19298		 Van der Pol (Carbamazepine) (Controls unexposed, disease free), 1991 Talipes throughout pregnancy prospective cohort unexposed, disease free excluded Adjustment: No Matched 5.19 [0.10;276.47] C
excluded (control group) 		0/11   0/55 0 11
ref
S6825
R19348		 Van der Pol (Carbamazepine) (Controls unexposed, sick), 1991 Talipes throughout pregnancy prospective cohort unexposed, sick Adjustment: No 2.05 [0.04;110.56] C 0/11   0/22 0 11
ref
Total 2 studies 2.72 [0.21;34.91] 2 23
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bànhidy (Carbamazepine), 2011Bànhidy, 2011 1 3.32[0.12; 91.61]21259%ROB confusion: criticalROB selection: criticalROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Van der Pol (Carbamazepine) (Controls unexposed, sick), 1991Van der Pol, 1991 2 2.05[0.04; 110.56]01141%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 2.72[0.21; 34.91]2230.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Carbamazepine; 2: Carbamazepine) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.05[0.04; 110.56]-11 -NAVan der Pol (Carbamazepine) (Controls unexposed, sick), 1991 1 case control studiescase control studies 3.32[0.12; 91.61]212 -NABànhidy (Carbamazepine), 2011 1 Type of controls unexposed, sickunexposed, sick 2.72[0.21; 34.91]2230%NABànhidy (Carbamazepine), 2011 Van der Pol (Carbamazepine) (Controls unexposed, sick), 1991 2 Tags Adjustment   - No  - No 2.72[0.21; 34.91]2230%NABànhidy (Carbamazepine), 2011 Van der Pol (Carbamazepine) (Controls unexposed, sick), 1991 2 MatchedMatched 3.32[0.12; 91.61]212 -NABànhidy (Carbamazepine), 2011 1 All studiesAll studies 2.72[0.21; 34.91]2230%NABànhidy (Carbamazepine), 2011 Van der Pol (Carbamazepine) (Controls unexposed, sick), 1991 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 6823

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 5.19[0.10; 276.47]-11 -NAVan der Pol (Carbamazepine) (Controls unexposed, disease free), 1991 1 unexposed, sick controlsunexposed, sick controls 2.72[0.21; 34.91]2230%NABànhidy (Carbamazepine), 2011 Van der Pol (Carbamazepine) (Controls unexposed, sick), 1991 20.510.01.0