Carbamazepine (Epilepsy)

Cleft lip with or without cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9830
R35235		 Vajda (Carbamazepine) (Controls unexposed, sick), 2013 Palate/lip malformation at least 1st trimester prospective cohort unexposed, sick Adjustment: No 0.41 [0.01;20.58] C 0/361   0/147 0 361
ref
S8411
R26710		 Jentink (Carbamazepine), 2010 Cleft lip (with or without palate) 1st trimester case control unexposed (general population or NOS) Adjustment: Yes no data 1/-   -/- - -
ref
S5529
R16228		 Viinikainen (Carbamazepine) (Controls unexposed, sick) a, 2006 Cleft lip throughout pregnancy prospective cohort unexposed, sick Adjustment: No 2.19 [0.09;54.89] C 1/72   0/52 1 72
ref
S302
R15854		 Artama (Carbamazepine), 2005 Cleft lip/ cleft palate 1st trimester retrospective cohort (registry) unexposed, sick Adjustment: No 0.23 [0.01;4.86] C 0/805   2/939 2 805
ref
Total 4 studies 0.59 [0.09;4.07] 3 1,238
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Vajda (Carbamazepine) (Controls unexposed, sick), 2013Vajda, 2013 1 0.41[0.01; 20.58]036124%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Jentink (Carbamazepine), 2010Jentink, 2010 2 0.20[0.00; 1.30]--0%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Viinikainen (Carbamazepine) (Controls unexposed, sick) a, 2006Viinikainen, 2006 3 2.19[0.09; 54.89]17236%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Artama (Carbamazepine), 2005Artama, 2005 4 0.23[0.01; 4.86]280540%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (4 studies) I2 = 0% 0.59[0.09; 4.07]31,2380.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Carbamazepine) (Controls unexposed, sick; 2: Carbamazepine; 3: Carbamazepine) (Controls unexposed, sick) ; 4: Carbamazepine;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.59[0.09; 4.07]31,2380%NAVajda (Carbamazepine) (Controls unexposed, sick), 2013 Viinikainen (Carbamazepine) (Controls unexposed, sick) a, 2006 Artama (Carbamazepine), 2005 3 case control studiescase control studies Jentink (Carbamazepine), 2010 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) Jentink (Carbamazepine), 2010 1 unexposed, sickunexposed, sick 0.59[0.09; 4.07]31,2380%NAVajda (Carbamazepine) (Controls unexposed, sick), 2013 Viinikainen (Carbamazepine) (Controls unexposed, sick) a, 2006 Artama (Carbamazepine), 2005 3 Tags Adjustment   - No  - No 0.59[0.09; 4.07]31,2380%NAVajda (Carbamazepine) (Controls unexposed, sick), 2013 Viinikainen (Carbamazepine) (Controls unexposed, sick) a, 2006 Artama (Carbamazepine), 2005 3   - Yes  - Yes Jentink (Carbamazepine), 2010 1 All studiesAll studies 0.59[0.09; 4.07]31,2380%NAVajda (Carbamazepine) (Controls unexposed, sick), 2013 Jentink (Carbamazepine), 2010 Viinikainen (Carbamazepine) (Controls unexposed, sick) a, 2006 Artama (Carbamazepine), 2005 40.15.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-4.94.42.5000.000Vajda (Carbamazepine) (Controls unexposed, sick), 2013Jentink (Carbamazepine), 2010Viinikainen (Carbamazepine) (Controls unexposed, sick) a, 2006Artama (Carbamazepine), 2005

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.59[0.09; 4.07]31,2380%NAVajda (Carbamazepine) (Controls unexposed, sick), 2013 Viinikainen (Carbamazepine) (Controls unexposed, sick) a, 2006 Artama (Carbamazepine), 2005 30.510.01.0