id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S15868 R65355 |
Dreier (Carbamazepine) (Epilepsy) (Controls exposed to LTG), 2023 | Autism spectrum disorder - Corresponding ICD-10 F-chapter - Up to 22 years of age | during pregnancy (anytime or not specified) | population based cohort propective | exposed to other treatment, sick excluded | Adjustment: No |
1.31 [0.88;1.93] C excluded (control group) |
42/2,665 64/5,288 | 106 | 2,665 |
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S15869 R65371 |
Dreier (Carbamazepine) (Epilepsy) (Controls unexposed, sick), 2023 | Autism spectrum disorder - Corresponding ICD-10 F-chapter - Up to 22 years of age | during pregnancy (anytime or not specified) | population based cohort propective | unexposed, sick | Adjustment: Yes | 1.03 [0.70;1.51] | 42/2,665 323/22,203 | 365 | 2,665 |
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S10075 R36696 |
Coste (Carbamazepine), 2020 | Diagnosis Pervasive developmental disorders (F84) (mean age of 3.7 years old) | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | exposed to other treatment, sick | Adjustment: No | 0.80 [0.05;14.03] C | 0/176 7/2,108 | 7 | 176 |
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S8024 R24431 |
Wiggs (Carbamazepine), 2020 | Austism Spectrum Disorder (after 2 years of age) | at least 1st trimester | population based cohort retrospective | unexposed, sick | Adjustment: Yes | 1.26 [0.88;1.79] | -/- -/11,298 | - | - |
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S7510 R22489 |
Huber-Mollema (Carbamazepine), 2019 | Diagnosis of autism spectrum disorder | throughout pregnancy | prospective cohort | exposed to other treatment, sick | Adjustment: No | 1.20 [0.21;6.85] C | 2/37 4/88 | 6 | 37 |
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S6181 R16275 |
Wood (Carbamazepine), 2015 | Score >30 (CARS) | during pregnancy (anytime or not specified) | prospective cohort | exposed to other treatment, sick | Adjustment: No | 0.78 [0.03;21.03] C | 1/34 0/9 | 1 | 34 |
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S6661 R35216 |
Bromley (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2013 | Autistic Spectrum Disorders (at 6 years old) | during pregnancy (anytime or not specified) | prospective cohort | exposed to other treatment, sick excluded | Adjustment: No |
0.19 [0.01;4.87] C excluded (control group) |
0/50 1/30 | 1 | 50 |
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S6660 R35217 |
Bromley (Carbamazepine) (Controls unexposed, disease free), 2013 | Autistic Spectrum Disorders (at 6 years old) | during pregnancy (anytime or not specified) | prospective cohort | unexposed, disease free excluded | Adjustment: No |
0.47 [0.02;8.88] C excluded (control group) |
0/50 4/214 | 4 | 50 |
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S5486 R35218 |
Bromley (Carbamazepine) (Controls unexposed, sick), 2013 | Autistic Spectrum Disorders (at 6 years old) | during pregnancy (anytime or not specified) | prospective cohort | unexposed, sick | Adjustment: No | 0.52 [0.01;26.73] C | 0/50 0/26 | 0 | 50 |
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Total | 6 studies | 1.14 [0.88;1.47] | 379 | 2,962 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Carbamazepine) (Epilepsy) (Controls unexposed, sick; 2: Carbamazepine; 3: Carbamazepine; 4: Carbamazepine; 5: Carbamazepine; 6: Carbamazepine) (Controls unexposed, sick;
Asymetry test p-value = 0.3240 (by Egger's regression)
slope=0.1914 (0.0751); intercept=-0.2642 (0.2350); t=1.1238; p=0.3240
excluded 6661, 6660, 15868