Methotrexate (Pre-conception only)

Intrauterine deaths (as a whole or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6697
R37886		 Svirsky, 2017 All abortions (early missed, late missed and induced) preconceptional for kinetic reason retrospective cohort unexposed, sick Adjustment: No Exposed group: MTX (monotherapy) MTX more than 3 months before pregnancy MTX treatment for ectopic pregnancy 0.18 [0.06;0.52] C 4/93   27/133 31 93
ref
S7243
R37885		 Svirsky, 2009 All abortions (early missed, late missed and late induced) preconceptional for kinetic reason retrospective cohort unexposed, sick Adjustment: No Exposed group: MTX (monotherapy) MTX more than 3 months before pregnancy MTX treatment for ectopic pregnancy 0.74 [0.29;1.88] C 8/45   18/80 26 45
ref
Total 2 studies 0.37 [0.09;1.53] 57 138
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Svirsky, 2017Svirsky, 2017 0.18[0.06; 0.52]319348%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Svirsky, 2009Svirsky, 2009 0.74[0.29; 1.88]264552%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 74% 0.37[0.09; 1.53]571380.02.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.37[0.09; 1.53]5713874%NASvirsky, 2017 Svirsky, 2009 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.37[0.09; 1.53]5713874%NASvirsky, 2017 Svirsky, 2009 2 Tags Adjustment   - No  - No 0.37[0.09; 1.53]5713874%NASvirsky, 2017 Svirsky, 2009 2 Exposed group   - MTX (monotherapy)  - MTX (monotherapy) 0.37[0.09; 1.53]5713874%NASvirsky, 2017 Svirsky, 2009 2 MTX more than 3 months before pregnancyMTX more than 3 months before pregnancy 0.37[0.09; 1.53]5713874%NASvirsky, 2017 Svirsky, 2009 2 MTX treatment for ectopic pregnancyMTX treatment for ectopic pregnancy 0.37[0.09; 1.53]5713874%NASvirsky, 2017 Svirsky, 2009 2 All studiesAll studies 0.37[0.09; 1.53]5713874%NASvirsky, 2017 Svirsky, 2009 20.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.37[0.09; 1.53]5713874%NASvirsky, 2017 Svirsky, 2009 20.510.01.0