Escitalopram updated on 07-01-2025

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18435
R78128		 Lee (Controls exposed to TCAs), 2025 Low birth weight (birth weight <2500 g) during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.47 [0.74;2.93] C
excluded (control group) 		11/71   68/613 79 71
ref
S18414
R77823		 Lee (Controls unexposed, general pop), 2025 Low birth weight (birth weight <2500 g) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.81 [0.95;3.46] 11/71   31,347/463,440 31,358 71
ref
S6190
R16316		 Klieger-Grossmann, 2012 Low birth weight (<2500 g) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Matched Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 5.13 [1.69;15.56] C 17/172   4/191 21 172
ref
Total 2 studies 2.75 [1.01;7.49] 31,379 243
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Lee (Controls unexposed, general pop), 2025Lee, 2025 1 1.81[0.95; 3.46]31,3587160%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Klieger-Grossmann, 2012Klieger-Grossmann, 2012 5.13[1.69; 15.56]2117240%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 60% 2.75[1.01; 7.49]31,3792430.520.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, general pop;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.75[1.01; 7.49]31,37924360%NALee (Controls unexposed, general pop), 2025 Klieger-Grossmann, 2012 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.75[1.01; 7.49]31,37924360%NALee (Controls unexposed, general pop), 2025 Klieger-Grossmann, 2012 2 Tags Adjustment   - No  - No 5.13[1.69; 15.56]21172 -NAKlieger-Grossmann, 2012 1   - Yes  - Yes 1.81[0.95; 3.45]31,35871 -NALee (Controls unexposed, general pop), 2025 1 MatchedMatched 5.13[1.69; 15.56]21172 -NAKlieger-Grossmann, 2012 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 2.75[1.01; 7.49]31,37924360%NALee (Controls unexposed, general pop), 2025 Klieger-Grossmann, 2012 2 All studiesAll studies 2.75[1.01; 7.49]31,37924360%NALee (Controls unexposed, general pop), 2025 Klieger-Grossmann, 2012 20.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18435

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.75[1.01; 7.49]31,37924360%NALee (Controls unexposed, general pop), 2025 Klieger-Grossmann, 2012 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.47[0.74; 2.93]7971 -NALee (Controls exposed to TCAs), 2025 10.510.01.0