Escitalopram updated on 07-01-2025

Early intrauterine deaths (< 22 weeks) / Spontaneous abortions

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12957
R49166		 Kitchin, 2022 Miscarriage (pregnancy losses between 4-22 weeks) 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 1.09 [0.82;1.45] 68/236   18,002/72,043 18,070 236
ref
S7520
R22542		 Ozturk, 2016 Miscarriages at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.09 [0.24;5.02] C 2/32   15/261 17 32
ref
S7868
R23811		 Andersen, 2014 Miscarriage (O021 and O03) early pregnancy population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 1.25 [1.09;1.42] -/2,377   139,210/1,256,956 - 2,377
ref
S6190
R16311		 Klieger-Grossmann, 2012 Spontaneous abortion during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Matched Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.91 [1.03;3.51] C 32/213   18/212 50 213
ref
S7882
R23832		 Yaris, 2005 Spontaneous abortions during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 25.11 [0.47;1334.55] C 0/1   9/248 9 1
ref
Total 5 studies 1.25 [1.04;1.50] 18,146 2,859
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kitchin, 2022Kitchin, 2022 1.09[0.82; 1.45]18,07023628%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Ozturk, 2016Ozturk, 2016 1.09[0.24; 5.02]17321%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Andersen, 2014Andersen, 2014 1.25[1.09; 1.42]-2,37762%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Klieger-Grossmann, 2012Klieger-Grossmann, 2012 1.91[1.03; 3.51]502138%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Yaris, 2005Yaris, 2005 25.11[0.47; 1334.55]910%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (5 studies) I2 = 19% 1.25[1.04; 1.50]18,1462,8590.5100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.40[0.99; 1.99]762,62324%NAOzturk, 2016 Andersen, 2014 Klieger-Grossmann, 2012 Yaris, 2005 4 case control studiescase control studies 1.09[0.82; 1.45]18,070236 -NAKitchin, 2022 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.25[1.04; 1.50]18,1462,85919%NAKitchin, 2022 Ozturk, 2016 Andersen, 2014 Klieger-Grossmann, 2012 Yaris, 2005 5 Tags Adjustment   - No  - No 1.86[0.97; 3.54]762466%NAOzturk, 2016 Klieger-Grossmann, 2012 Yaris, 2005 3   - Yes  - Yes 1.22[1.08; 1.38]18,0702,6130%NAKitchin, 2022 Andersen, 2014 2 MatchedMatched 1.91[1.03; 3.51]50213 -NAKlieger-Grossmann, 2012 1 Monotherapy   - no or not specified  - no or not specified 1.22[1.08; 1.38]18,0962,6460%NAKitchin, 2022 Ozturk, 2016 Andersen, 2014 Yaris, 2005 4   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.91[1.03; 3.51]50213 -NAKlieger-Grossmann, 2012 1 All studiesAll studies 1.25[1.04; 1.50]18,1462,85919%NAKitchin, 2022 Ozturk, 2016 Andersen, 2014 Klieger-Grossmann, 2012 Yaris, 2005 50.5100.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-4.85.02.4330.000Kitchin, 2022Ozturk, 2016Andersen, 2014Klieger-Grossmann, 2012Yaris, 2005

Asymetry test p-value = 0.3480 (by Egger's regression)

slope=0.1442 (0.0922); intercept=0.7647 (0.6889); t=1.1099; p=0.3480

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.25[1.04; 1.50]157,3472,85919%NAKitchin, 2022 Ozturk, 2016 Andersen, 2014 Klieger-Grossmann, 2012 Yaris, 2005 50.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Xing (Spontaneous abortion)Xing (Spontaneous abortion) 1.48[1.16; 1.88]78%-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT3 metaPregmetaPreg 1.25[1.04; 1.50]19%2,859----Kitchin, 2022 Ozturk, 2016 Andersen, 2014 Klieger-Grossmann, 2012 Yaris, 2005 50.510.01.0