Escitalopram updated on 07-01-2025

Transposition of the great vessels

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7353
R21566		 Wemakor, 2015 Transposition of great vessels (complete) 1st trimester case control unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 3.09 [0.39;24.43] C 1/10   614/17,688 615 10
ref
S6245
R16531		 Malm, 2011 Transposition of the great vessels 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 2.99 [0.19;48.03] C 0/441   238/628,607 238 441
ref
Total 2 studies 3.05 [0.58;16.03] 853 451
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Wemakor, 2015Wemakor, 2015 3.09[0.39; 24.43]6151064%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Malm, 2011Malm, 2011 2.99[0.19; 48.03]23844136%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 3.05[0.58; 16.03]8534510.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.99[0.19; 48.03]238441 -NAMalm, 2011 1 case control studiescase control studies 3.09[0.39; 24.43]61510 -NAWemakor, 2015 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.05[0.58; 16.03]8534510%NAWemakor, 2015 Malm, 2011 2 Tags Adjustment   - No  - No 3.05[0.58; 16.03]8534510%NAWemakor, 2015 Malm, 2011 2 Monotherapy   - no or not specified  - no or not specified 2.99[0.19; 48.03]238441 -NAMalm, 2011 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 3.09[0.39; 24.43]61510 -NAWemakor, 2015 1 All studiesAll studies 3.05[0.58; 16.03]8534510%NAWemakor, 2015 Malm, 2011 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.05[0.58; 16.03]8534510%NAWemakor, 2015 Malm, 2011 20.510.01.0