Escitalopram updated on 07-01-2025

Cardiac septal defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7472
R22337		 Anderson, 2020 Septal defects 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.78 [0.39;1.59] -/-   0/- - -
ref
S6009
R15439		 Furu, 2015 Atrial and ventricular septal defects 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.82 [0.54;1.25] 28/3,950   17,503/2,266,875 17,531 3,950
ref
S7353
R21576		 Wemakor, 2015 Septal defects 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.62 [0.60;4.36] 7/16   8,124/25,198 8,131 16
ref
Total 3 studies 0.88 [0.63;1.23] 25,662 3,966
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 0.78[0.39; 1.59]--23%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Furu, 2015Furu, 2015 0.82[0.54; 1.25]17,5313,95065%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Wemakor, 2015Wemakor, 2015 1.62[0.60; 4.36]8,1311612%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 0.88[0.63; 1.23]25,6623,9660.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.82[0.54; 1.25]17,5313,950 -NAFuru, 2015 1 case control studiescase control studies 1.03[0.51; 2.07]8,1311628%NAAnderson, 2020 Wemakor, 2015 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.88[0.63; 1.23]25,6623,9660%NAAnderson, 2020 Furu, 2015 Wemakor, 2015 3 Tags Adjustment   - Yes  - Yes 0.88[0.63; 1.23]25,6623,9660%NAAnderson, 2020 Furu, 2015 Wemakor, 2015 3 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 0.88[0.63; 1.23]25,6623,9660%NAAnderson, 2020 Furu, 2015 Wemakor, 2015 3 All studiesAll studies 0.88[0.63; 1.23]25,6623,9660%NAAnderson, 2020 Furu, 2015 Wemakor, 2015 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.88[0.63; 1.23]25,6623,9660%NAAnderson, 2020 Furu, 2015 Wemakor, 2015 30.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Reefhuis (Septal defects)Reefhuis (Septal defects) 1.30[0.70; 2.10]NA-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT3 metaPregmetaPreg 0.88[0.63; 1.23]0%3,966----Anderson, 2020 Furu, 2015 Wemakor, 2015 30.510.01.0