Escitalopram updated on 07-01-2025

Atrioventricular septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7353
R21574		 Wemakor, 2015 Atrioventricular septal defect 1st trimester case control unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 3.10 [0.18;53.46] C 0/9   290/17,364 290 9
ref
S6015
R15641		 Jimenez-Solem (Controls unexposed, NOS), 2012 Atrioventricular septal defects 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 8.71 [1.21;62.64] 1/293   -/843,797 - 293
ref
Total 2 studies 6.23 [1.23;31.54] 290 302
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Wemakor, 2015Wemakor, 2015 3.10[0.18; 53.46]290932%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Jimenez-Solem (Controls unexposed, NOS), 2012Jimenez-Solem, 2012 1 8.71[1.21; 62.64]-29368%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: critical Total (2 studies) I2 = 0% 6.23[1.23; 31.54]2903020.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 8.71[1.21; 62.67]-293 -NAJimenez-Solem (Controls unexposed, NOS), 2012 1 case control studiescase control studies 3.10[0.18; 53.46]2909 -NAWemakor, 2015 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 6.23[1.23; 31.54]2903020%NAWemakor, 2015 Jimenez-Solem (Controls unexposed, NOS), 2012 2 Tags Adjustment   - No  - No 3.10[0.18; 53.46]2909 -NAWemakor, 2015 1   - Yes  - Yes 8.71[1.21; 62.67]-293 -NAJimenez-Solem (Controls unexposed, NOS), 2012 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 3.10[0.18; 53.46]2909 -NAWemakor, 2015 1   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 8.71[1.21; 62.67]-293 -NAJimenez-Solem (Controls unexposed, NOS), 2012 1 All studiesAll studies 6.23[1.23; 31.54]2903020%NAWemakor, 2015 Jimenez-Solem (Controls unexposed, NOS), 2012 20.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 6.23[1.23; 31.54]2903020%NAWemakor, 2015 Jimenez-Solem (Controls unexposed, NOS), 2012 20.510.01.0