Escitalopram updated on 07-01-2025

Club foot / Talipes equinovarus

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7353
R21557		 Wemakor, 2015 Club foot 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 3.88 [1.19;12.69] 4/13   1,988/19,062 1,992 13
ref
S7908
R23945		 Yazdy, 2014 Club foot 1st trimester case control unexposed, disease free Adjustment: Yes Monotherapy: no or not specified 2.90 [1.10;7.20] 9/20   613/2,604 622 20
ref
Total 2 studies 3.25 [1.56;6.77] 2,614 33
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Wemakor, 2015Wemakor, 2015 3.88[1.19; 12.69]1,9921339%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Yazdy, 2014Yazdy, 2014 2.90[1.10; 7.20]6222061%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 3.25[1.56; 6.77]2,614330.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 3.25[1.56; 6.77]2,614330%NAWemakor, 2015 Yazdy, 2014 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.25[1.56; 6.77]2,614330%NAWemakor, 2015 Yazdy, 2014 2 Tags Adjustment   - Yes  - Yes 3.25[1.56; 6.77]2,614330%NAWemakor, 2015 Yazdy, 2014 2 Monotherapy   - no or not specified  - no or not specified 2.90[1.13; 7.42]62220 -NAYazdy, 2014 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 3.88[1.19; 12.67]1,99213 -NAWemakor, 2015 1 All studiesAll studies 3.25[1.56; 6.77]2,614330%NAWemakor, 2015 Yazdy, 2014 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.25[1.56; 6.77]2,614330%NAWemakor, 2015 Yazdy, 2014 20.510.01.0