Fluvoxamine updated on 07-01-2025

Early intrauterine deaths (< 22 weeks) / Spontaneous abortions

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8179
R25340
Nakhai-Pour, 2010 Spontaneous abortions (< 20th week of gestation) during pregnancy (anytime or not specified) nested case control unexposed (general population or NOS) Adjustment: Yes Matched Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 2.19 [0.79;6.08] 5/-   5,119/- 5,124 -
ref
S7879
R23826
Yaris, 2005 Spontaneous abortions during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 3.32 [0.37;29.45] C 1/9   9/248 10 9
ref
Total 2 studies 2.36 [0.94;5.95] 5,134 9
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Nakhai-Pour, 2010Nakhai-Pour, 2010 2.19[0.79; 6.08]5,124-82%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Yaris, 2005Yaris, 2005 3.32[0.37; 29.45]10918%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 2.36[0.94; 5.95]5,13490.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.32[0.37; 29.45]109 -NAYaris, 2005 1 case control studiescase control studies 2.19[0.79; 6.08]5,124- -NANakhai-Pour, 2010 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.36[0.94; 5.95]5,13490%NANakhai-Pour, 2010 Yaris, 2005 2 Tags Adjustment   - No  - No 3.32[0.37; 29.45]109 -NAYaris, 2005 1   - Yes  - Yes 2.19[0.79; 6.08]5,124- -NANakhai-Pour, 2010 1 MatchedMatched 2.19[0.79; 6.08]5,124- -NANakhai-Pour, 2010 1 Monotherapy   - no or not specified  - no or not specified 3.32[0.37; 29.45]109 -NAYaris, 2005 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 2.19[0.79; 6.08]5,124- -NANakhai-Pour, 2010 1 All studiesAll studies 2.36[0.94; 5.95]5,13490%NANakhai-Pour, 2010 Yaris, 2005 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.36[0.94; 5.95]5,13490%NANakhai-Pour, 2010 Yaris, 2005 20.510.01.0