Fluvoxamine updated on 07-01-2025

Nervous system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7440
R21963		 Bérard, 2017 Nervous system malformations 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 2.44 [0.33;18.11] -/55   -/14,847 - 55
ref
S6247
R16565		 Malm, 2011 Central nervous system 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 2.34 [0.58;9.49] -/240   -/628,607 - 240
ref
Total 2 studies 2.37 [0.75;7.46] 0 295
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bérard, 2017Bérard, 2017 2.44[0.33; 18.11]-5533%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Malm, 2011Malm, 2011 2.34[0.58; 9.49]-24067%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 2.37[0.75; 7.46]-2950.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.37[0.75; 7.46]-2950%NABérard, 2017 Malm, 2011 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.34[0.58; 9.47]-240 -NAMalm, 2011 1 unexposed, sickunexposed, sick 2.44[0.33; 18.08]-55 -NABérard, 2017 1 Tags Adjustment   - Yes  - Yes 2.37[0.75; 7.46]-2950%NABérard, 2017 Malm, 2011 2 Monotherapy   - no or not specified  - no or not specified 2.34[0.58; 9.47]-240 -NAMalm, 2011 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 2.44[0.33; 18.08]-55 -NABérard, 2017 1 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 2.44[0.33; 18.08]-55 -NABérard, 2017 1 All studiesAll studies 2.37[0.75; 7.46]-2950%NABérard, 2017 Malm, 2011 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.34[0.58; 9.47]-240 -NAMalm, 2011 1 unexposed, sick controlsunexposed, sick controls 2.44[0.33; 18.08]-55 -NABérard, 2017 10.510.01.0