Tramadol (versus unexposed) updated on 07-09-2025

Limb defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18427
R78029		 Ferrer, 2025 Musculoskeletal system anomalies at least 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 0.98 [0.32;3.07] C 3/999   466/152,811 469 999
ref
S13280
R51160		 Sørensen, 2022 Limb malformations 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 0.90 [0.59;1.36] 27/3,796   120/15,111 147 3,796
ref
Total 2 studies 0.91 [0.61;1.35] 616 4,795
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ferrer, 2025Ferrer, 2025 0.98[0.32; 3.07]46999912%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Sørensen, 2022Sørensen, 2022 0.90[0.59; 1.36]1473,79688%ROB confusion: moderateROB selection: moderateROB classification: criticalROB missing: moderateROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.91[0.61; 1.35]6164,7950.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.91[0.61; 1.35]6164,7950%NAFerrer, 2025 Sørensen, 2022 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.91[0.61; 1.35]6164,7950%NAFerrer, 2025 Sørensen, 2022 2 Tags Adjustment   - No  - No 0.98[0.32; 3.07]469999 -NAFerrer, 2025 1   - Yes  - Yes 0.90[0.59; 1.37]1473,796 -NASørensen, 2022 1 All studiesAll studies 0.91[0.61; 1.35]6164,7950%NAFerrer, 2025 Sørensen, 2022 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.91[0.61; 1.35]6164,7950%NAFerrer, 2025 Sørensen, 2022 20.510.01.0