Tramadol (versus unexposed) updated on 07-09-2025

Abdominal wall defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18427
R78026		 Ferrer, 2025 Abdominal wall defect at least 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 2.69 [0.37;19.41] C 1/999   57/152,811 58 999
ref
Total 1 studies 2.69 [0.37;19.41] 58 999
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ferrer, 2025Ferrer, 2025 2.69[0.37; 19.41]589990%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.69[0.37; 19.41]58999 -NAFerrer, 2025 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.69[0.37; 19.41]58999 -NAFerrer, 2025 1 Tags Adjustment   - No  - No 2.69[0.37; 19.41]58999 -NAFerrer, 2025 1 All studiesAll studies 2.69[0.37; 19.41]58999 -NAFerrer, 2025 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.69[0.37; 19.41]58999 -NAFerrer, 2025 10.510.01.0