Lansoprazole

All congenital malformations (majors, minors, majors and minors, or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14456
R57402
Choi a, 2023 Major congenital malformations 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes 1.01 [0.89;1.15] 233/6,404   85,900/2,655,676 86,133 6,404
ref
S4448
R13175
Matok, 2012 Major malformations (according to CDC definitions) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 0.83 [0.48;1.46] 13/233   6,753/110,550 6,766 233
ref
S4410
R13176
Pasternak, 2010 Major birth defects (Exposure during First Trimester) 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 1.13 [0.77;1.67] 28/794   21,867/837,317 21,895 794
ref
S4429
R28447
Diav-Citrin, 2005 Major anomalies 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No 1.21 [0.28;5.23] C 2/44   30/792 32 44
ref
Total 4 studies 1.01 [0.90;1.14] 114,826 7,475
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Choi a, 2023Choi a, 2023 1.01[0.89; 1.15]86,1336,40485%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: NAROB reporting: NA Matok, 2012Matok, 2012 0.83[0.48; 1.46]6,7662335%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2010Pasternak, 2010 1.13[0.77; 1.67]21,8957949%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Diav-Citrin, 2005Diav-Citrin, 2005 1.21[0.28; 5.23]32441%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (4 studies) I2 = 0% 1.01[0.90; 1.14]114,8267,4750.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.01[0.90; 1.14]114,8267,4750%NAChoi a, 2023 Matok, 2012 Pasternak, 2010 Diav-Citrin, 2005 4 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.03[0.75; 1.40]28,6931,0710%NAMatok, 2012 Pasternak, 2010 Diav-Citrin, 2005 3 unexposed, sickunexposed, sick 1.01[0.89; 1.15]86,1336,404 -NAChoi a, 2023 1 Tags Adjustment   - No  - No 1.21[0.28; 5.23]3244 -NADiav-Citrin, 2005 1   - Yes  - Yes 1.01[0.90; 1.14]114,7947,4310%NAChoi a, 2023 Matok, 2012 Pasternak, 2010 3 All studiesAll studies 1.01[0.90; 1.14]114,8267,4750%NAChoi a, 2023 Matok, 2012 Pasternak, 2010 Diav-Citrin, 2005 40.25.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-1.81.80.8970.000Choi a, 2023Matok, 2012Pasternak, 2010Diav-Citrin, 2005

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.03[0.75; 1.40]28,6931,0710%NAMatok, 2012 Pasternak, 2010 Diav-Citrin, 2005 3 unexposed, sick controlsunexposed, sick controls 1.01[0.89; 1.15]86,1336,404 -NAChoi a, 2023 10.510.01.0