Clomiphene

Neuroblastoma

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15728
R64930		 Olshan, 1999 Neuroblastoma preconceptional for kinetic reason case control unexposed (general population or NOS) Adjustment: Yes Clomiphene exposure: 1 month before pregnancy Clomiphene indications: Ovarian stimulation for infertility (NOS) Matched 0.50 [0.20;1.20] 7/21   452/897 459 21
ref
Total 1 studies 0.50 [0.20;1.22] 459 21
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Olshan, 1999Olshan, 1999 0.50[0.20; 1.20]459210%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: moderateROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.50[0.20; 1.22]45921 -NAOlshan, 1999 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.50[0.20; 1.22]45921 -NAOlshan, 1999 1 Tags Adjustment   - Yes  - Yes 0.50[0.20; 1.22]45921 -NAOlshan, 1999 1 Clomiphene exposure   - 1 month before pregnancy  - 1 month before pregnancy 0.50[0.20; 1.22]45921 -NAOlshan, 1999 1 Clomiphene indications   - Ovarian stimulation for infertility ...  - Ovarian stimulation for infertility (NOS) 0.50[0.20; 1.22]45921 -NAOlshan, 1999 1 MatchedMatched 0.50[0.20; 1.22]45921 -NAOlshan, 1999 1 All studiesAll studies 0.50[0.20; 1.22]45921 -NAOlshan, 1999 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.50[0.20; 1.22]45921 -NAOlshan, 1999 10.510.01.0