Antimycotic Azoles (all routes except local only) updated on 01-29-2025

Small for gestational age (weight)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17743
R75023		 Santos - Fluconazole, 2011 Small for gestational age (weight adjusted for gestational age and gender < 10th percentile) 2nd and/or 3rd trimester nested case control unexposed (general population or NOS) Adjustment: Yes Fluconazole not specified or mixed dose 1.34 [0.85;2.12] 25/120   8,167/63,218 8,192 120
ref
Total 1 studies 1.34 [0.85;2.12] 8,192 120
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Santos - Fluconazole, 2011Santos - Fluconazole, 2011 1.34[0.85; 2.12]8,1921200%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.34[0.85; 2.12]8,192120 -NASantos - Fluconazole, 2011 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.34[0.85; 2.12]8,192120 -NASantos - Fluconazole, 2011 1 Tags Adjustment   - Yes  - Yes 1.34[0.85; 2.12]8,192120 -NASantos - Fluconazole, 2011 1 Fluconazole not specified or mixed doseFluconazole not specified or mixed dose 1.34[0.85; 2.12]8,192120 -NASantos - Fluconazole, 2011 1 All studiesAll studies 1.34[0.85; 2.12]8,192120 -NASantos - Fluconazole, 2011 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.34[0.85; 2.12]8,192120 -NASantos - Fluconazole, 2011 10.510.01.0