Antimycotic Azoles (all routes except local only) updated on 01-29-2025

Hydrocephaly

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17734
R74855		 Howley - Fluconazole, 2016 Hydrocephaly 1st trimester case control unexposed (general population or NOS) Adjustment: No Fluconazole not specified or mixed dose 3.73 [0.45;31.08] C 1/7   518/12,124 519 7
ref
Total 1 studies 3.73 [0.45;31.08] 519 7
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Howley - Fluconazole, 2016Howley - Fluconazole, 2016 3.73[0.45; 31.08]51970%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 3.73[0.45; 31.08]5197 -NAHowley - Fluconazole, 2016 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.73[0.45; 31.08]5197 -NAHowley - Fluconazole, 2016 1 Tags Adjustment   - No  - No 3.73[0.45; 31.08]5197 -NAHowley - Fluconazole, 2016 1 Fluconazole not specified or mixed doseFluconazole not specified or mixed dose 3.73[0.45; 31.08]5197 -NAHowley - Fluconazole, 2016 1 All studiesAll studies 3.73[0.45; 31.08]5197 -NAHowley - Fluconazole, 2016 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.73[0.45; 31.08]5197 -NAHowley - Fluconazole, 2016 10.510.01.0