Antimycotic Azoles (all routes except local only) updated on 01-29-2025

Neonatal death (< 28 days of life)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17742
R75022		 Pasternak - Fluconazole, 2018 Neonatal death (0-27 days after live birth) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Fluconazole not specified or mixed dose Matched 0.73 [0.42;1.29] 13/10,640   177/106,387 190 10,640
ref
Total 1 studies 0.73 [0.42;1.28] 190 10,640
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Pasternak - Fluconazole, 2018Pasternak - Fluconazole, 2018 0.73[0.42; 1.29]19010,6400%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.73[0.42; 1.28]19010,640 -NAPasternak - Fluconazole, 2018 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.73[0.42; 1.28]19010,640 -NAPasternak - Fluconazole, 2018 1 Tags Adjustment   - Yes  - Yes 0.73[0.42; 1.28]19010,640 -NAPasternak - Fluconazole, 2018 1 Fluconazole not specified or mixed doseFluconazole not specified or mixed dose 0.73[0.42; 1.28]19010,640 -NAPasternak - Fluconazole, 2018 1 MatchedMatched 0.73[0.42; 1.28]19010,640 -NAPasternak - Fluconazole, 2018 1 All studiesAll studies 0.73[0.42; 1.28]19010,640 -NAPasternak - Fluconazole, 2018 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.73[0.42; 1.28]19010,640 -NAPasternak - Fluconazole, 2018 10.510.01.0